Trazodone and hydroxyzine

Gabapentin, also known аs Neurontin, is an anticonvulsant medication used to treat seizures and nerve pain. It works by affecting chemicals and nerves in the body. Gabapentin is available in various forms, including oral solution, cаpsules, and extended-release tablets.

Other off-label medications used by doctors for sleep include Trazodone and Doxepin. There are two types of this medication: Hydroxyzine Hydrochloride (Atarax) and Hydroxyzine Pamoate (Vistaril). They work very similarly, though Vistaril is more commonly prescribed for anxiety and sleep. It is not a controlled substance.antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine, olopatadine, rupatadine); anti-Parkinson's medications (e.g. ...hydrOXYzine lurasidone. Applies to: hydroxyzine and Latuda (lurasidone) Using hydrOXYzine together with lurasidone may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems.Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during pregnancy or while breastfeeding unless the benefits outweigh the risks. 5. Tips. May be taken with or without food.According to the experts, there are no harmful hydroxyzine interactions with caffeine. “There is no significant interaction between hydroxyzine and caffeine,” says Brandon Cometti, MD, a dermatologist at Roswell Skin Center in New Mexico. “Hydroxyzine is a sedating antihistamine, so it can make you drowsy, while caffeine is a …There are 647 drugs known to interact with trazodone, along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 136 are major, 496 are …

100mg. 300mg. 400mg. Overview. Gabapentin is used for many different conditions including nerve pain, seizures, migraines, restless leg syndrome, and insomnia. It releases a calming effect that can lead to deeper, uninterrupted sleep. Gabapentin is not a controlled substance. Prescribing this medication for insomnia is an off-label usage.Atypical antidepressants are safe for most people. However, in some circumstances they can cause problems. For example: Bupropion should not be used by people who have a seizure disorder or an eating disorder such as bulimia or anorexia.; Esketamine can cause serious side effects and must be administered by a psychiatrist or …Trazodone may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use trazodone with buspirone (Buspar®), fentanyl (Abstral®, …Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. ... Trazodone Triclabendazole Trimipramine Triptorelin Vandetanib Vardenafil Vemurafenib Venlafaxine Vilanterol Vinflunine Voclosporin Voriconazole Vorinostat Zolpidem ...Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the mouth, stuffy nose, constipation, or change ...More about Promethazine. Ratings & Reviews. Hydroxyzine has an average rating of 5.7 out of 10 from a total of 1375 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 36% reported a negative effect. Promethazine has an average rating of 7.3 out of 10 from a total of 380 ratings on Drugs.com. 65% of reviewers reported a ...Buspirone has an average rating of 5.9 out of 10 from a total of 1334 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 36% reported a negative effect. Hydroxyzine has an average rating of 5.7 out of 10 from a total of 1375 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 36% reported a negative ...

The days of simple, inconvenience-free flying have been gone for awhile, but the latest security measures have elevated personal privacy concerns. Here's what you need to know abou...Applies to: doxepin and hydroxyzine. Using doxepin together with hydrOXYzine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to ...I told my primary care doctor my sleeping was still interrupted for various reasons in the night. Hydroxyzine is also a new medication I just started a few days ago. But my PC doctor prescribed me Trazadone to help me sleep at night. I am reluctant to take this because they say their is an interraction between them related to heart issues.A dose of 25mg hydroxyzine at bedtime may: reduce sleep onset time. increase total sleep time. raise sleep efficiency (the amount of time spent sleeping, relative to the time spent in bed). 6. It’s worth noting that there are few longer term studies into the efficacy and safety of hydroxyzine for insomnia.

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a seizure (convulsions). Side effects such as drowsiness and confusion may be more likely in older adults. Common hydroxyzine side effects may include: drowsiness; headache; dry mouth; or. skin rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.Applies to: hydroxyzine and gabapentin. Using hydrOXYzine together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while ...In pooled results, trazodone monotherapy appeared more likely than placebo to lead to a ‘positive treatment response’, although this difference was not statistically significant (37% vs 20%; relative benefit increase, 1.6; 95% confidence interval, CI, 0.8–3.3). Subgroup analyses suggested that men with psychogenic ED might be …Drugs that may interact with trazodone oral tablet include: hydroxyzine (Vistaril): what might happen: can increase the risk of side effects from trazodone and hydroxyzine, including long QT syndrome (a type of irregular heart rhythm) anticoagulants: drug examples: rivaroxaban , warfarin (Jantoven)

Other off-label medications used by doctors for sleep include Trazodone and Doxepin. There are two types of this medication: Hydroxyzine Hydrochloride (Atarax) and Hydroxyzine Pamoate (Vistaril). They work very similarly, though Vistaril is more commonly prescribed for anxiety and sleep. It is not a controlled substance.More about Mirtazapine. Ratings & Reviews. Hydroxyzine has an average rating of 5.7 out of 10 from a total of 1375 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 36% reported a negative effect. Mirtazapine has an average rating of 6.8 out of 10 from a total of 2023 ratings on Drugs.com. 56% of reviewers reported a ...Hydroxyzine is an antihistamine which treats allergies, but has the sleepy qualities like a night time cold over the counter medicine would have. The trazodone doesn’t knock me out, but makes it easier to fall asleep. I’ve used both to help insomnia/ sleep paralysis. 3. Reply. Share. SessionWitty534. • 3 yr. ago.The following applies to the ingredients: Trazodone. Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with traZODone.phenhydramine, doxylamine, and hydroxyzine, are fre-quently used for their sedative properties. Although this class of drugs is known for causing acetylcholine receptor (AChR) antagonism, it is important to note that these drugs display selectivity for the muscarinic AChR, not the nico-tinic AChR (15). In other words, while they may cause10 Jan 2019 ... The most commonly prescribed noncontrolled medication was trazodone (5,190 prescriptions), followed by hydroxyzine (2,539), and quetiapine ( ...Hydroxyzine is like the previous generation of benadryl, it's an antihistamine that makes some people drowsy - safe choice for insomnia. Trazodone (like seroquel) is stronger but still a safe choice for insomnia. Remeron is for both depression and can help with sleep, another good choice. (It's a good sign you have the above three vs the easy ...Cognitive impairment: In addition to making someone sleepy, Z drugs can cause loss of balance and reduced mental alertness, which may make someone prone to falls or other inadvertent injury. Dependence: People can become addicted to Z drugs, leading them to take them for longer or at higher doses than indicated.Applies to: doxepin and hydroxyzine. Using doxepin together with hydrOXYzine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to ...

Hydroxyzine is an antihistamine which treats allergies, but has the sleepy qualities like a night time cold over the counter medicine would have. The trazodone doesn’t knock me out, but makes it easier to fall asleep. I’ve used both to help insomnia/ sleep paralysis. 3. Reply. Share. SessionWitty534. • 3 yr. ago.

1 Mar 2014 ... This was true for clonidine throughout the titrations as well as the hydroxyzine trial. Trazodone produced a paradoxical effect of hyperactivity ...Trazadone and mirtazapine both made my insomnia even worse. I stayed up like 2 days straight from 100 mg Trazodone and felt really weird. Seroquel wouldn't work unless I took 100- 200mg and then even if I slept 8-10 hours I was still a zombie. Hydroxizine worked for a while.Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses).Hydroxyzine can cause both an increase and decrease in heart rate. The European Medicines Agency (EMA) found that this drug can prolong the QT interval and increase the torsades de pointes (TdP) —in other words, this medicine can lengthen the time between two crucial electrical signals that recharge the heart.Gabapentin is an anticonvulsive medication that is primarily used to treat seizures and nerve pain. It was initially developed as a muscle relaxer and anti-spasmodic medication, but its anticonvulsive properties were discovered later. Gabapentin is also used as an adjunct to more potent anticonvulsants and for the management of certain types of ...Trazodone is an antidepressant medicine. Sometimes, it is used as a sleep aid and to treat agitation in people with dementia. Trazodone overdose occurs when someone takes more than...Trazodone And Hydroxyzine. Trazodone and Hydroxyzine interactions are considered drug-drug. Trazodone is an antidepressant that is used to reduce anxiety and it works by balancing the serotonin levels in the brain. Taking Trazodone and Hydroxyzine together increases the risk of irregular heart rhythm to occur. Although this is rare and depends ...

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Trazodone is a weak but specific inhibitor of serotonin (5-HT) reuptake and has antagonistic actions at the H 1, 5-HT 1A, 5-HT 1C, and 5-HT 2A receptors, as well as the α 1-adrenoceptors and α 2-adrenoceptors. 19 The H 1, 5-HT 2A, and α 1 antagonistic pharmacologic properties make trazodone effective for insomnia, but the α-blocking ...Using hydrOXYzine together with methocarbamol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications ...Objective: The purpose of this systematic review is to assess the efficacy and safety of hydroxyzine for insomnia in adults. Methods: A comprehensive literature search of PubMed, Embase, and CENTRAL databases was conducted to identify relevant published studies through October 2022 using the search terms: hydroxyzine and sleep, insomnia, …5 ounces of wine (12% alcohol) 1 1/2 ounces of liquor (40% alcohol) 12 ounces of beet (5% alcohol) The alcohol percent in the above drinks can certainly vary, but it gives you a good measuring stick. Therefore, if you have one drink, you want to wait at least one hour before taking trazodone. Two hours for two drinks, and so on.Hydroxyzine starts to work in about 15 to 30 minutes but its drowsy effect may last for 4 to 6 hours. Hydroxyzine can reduce itching and redness due to allergy skin tests for up to 4 days. Hydroxyzine is used to relieve anxiety, itching due to allergies, and as a premedication prior to surgery.cloNIDine hydrOXYzine. Applies to: clonidine and hydroxyzine. CloNIDine and hydrOXYzine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, …Do Hydroxyzine Pam and trazodone combine well? Hydroxyzine Pam is an anti-anxiety drug usually called by another name - Answered by a verified Doctor. We use cookies to give you the best possible experience on our website. Gabapentin is an anticonvulsive medication that is primarily used to treat seizures and nerve pain. It was initially developed as a muscle relaxer and anti-spasmodic medication, but its anticonvulsive properties were discovered later. Gabapentin is also used as an adjunct to more potent anticonvulsants and for the management of certain types of ... Hydroxyzine: learn about side effects, dosage, special precautions, and more on MedlinePlus Hydroxyzine is used in adults and children to relieve itching caused by allergic skin re... traZODone hydrOXYzine. Applies to: trazodone and Vistaril (hydroxyzine) Using traZODone together with hydrOXYzine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome ... Key Differences of Trazodone Vs. Hydroxyzine. Trazodone and hydroxyzine are both medications used to treat sleep disorders, but they work differently and have their unique advantages. Trazodone. Trazodone is an antidepressant medication that belongs to a class of drugs known as serotonin antagonists and reuptake inhibitors (SARIs). It is ... ….

Gabapentin, also known аs Neurontin, is an anticonvulsant medication used to treat seizures and nerve pain. It works by affecting chemicals and nerves in the body. Gabapentin is available in various forms, including …Gabapentin is an anticonvulsive medication that is primarily used to treat seizures and nerve pain. It was initially developed as a muscle relaxer and anti-spasmodic medication, but its anticonvulsive properties were discovered later. Gabapentin is also used as an adjunct to more potent anticonvulsants and for the management of certain types of ...hydrOXYzine traMADol. Applies to: hydroxyzine and tramadol. Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including profound sedation, respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns.Hydroxyzine Ibutilide Imipramine Inotuzumab Ozogamicin Itraconazole Ivabradine Ivosidenib Ketoconazole Lefamulin Lenvatinib Leuprolide Levofloxacin Linezolid ... Trazodone Triclabendazole Trifluoperazine Trimethoprim Trimipramine Triptorelin Vandetanib Vardenafil Vemurafenib Venlafaxine Vilanterol Vinflunine ...Trazodone Trofinetide Venlafaxine Vilazodone Vortioxetine Ziprasidone Zolpidem Zuranolone Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often …Applies to: doxepin and hydroxyzine. Using doxepin together with hydrOXYzine may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Side effects may be more likely to ...Yahoo Finance tech reporter Dan Howley breaks down Elon Musk's latest tweet which stated that his Twitter deal was on hold while he investigates spam account numbers. Yahoo Finance...Hydroxyzine dosage for anxiety. Hydroxyzine is an as-needed anxiety treatment. This is different from many other anti-anxiety medications that need to be taken regularly to be effective. The typical adult hydroxyzine dosage for anxiety is 50 mg to 100 mg 4 times daily as needed. You can take it with or without food. Trazodone and hydroxyzine, Jul 1, 2017 · The most commonly prescribed class of medication for insomnia is the so-called z-drugs, zaleplon (Sonata), zolpidem (Ambien), and eszopiclone (Lunesta). 21 Numerous trials have demonstrated the... , dizziness. fainting. fast heartbeat. hives, itching, or skin rash. irregular or slow heart rate. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. trouble breathing. unusual tiredness or weakness. Get emergency help immediately if any of the following symptoms of overdose occur:, Hydroxyzine (Vistaril) is a medication used for allergies, itching, and anxiety. It interacts with several medications and alcohol. Opioid pain medications and other antihistamines, such as diphenhydramine (Benadryl), interact with hydroxyzine. Combining them can cause severe drowsiness and raise the chance of accidental injuries., Mechanisms of action of gabapentin. Gabapentin is an anticonvulsant drug that reduces synaptic transmission by decreasing presynaptic voltage-gated Ca 2+ and Na + channels. 2 – 4 Besides, gabapentin reduces exocytosis and the discharge of neurotransmitter from presynaptic terminals. 5, 6 On the other hand, another line of …, Trazodone can be lethal if more then the prescribed dose is taken, but instances are rare, according to MedlinePlus. The average dose for an outpatient adult ranges from 150 millig..., For oral dosage form (capsules, tablets, or solution): For anxiety and tension: Adults—50 to 100 milligrams (mg) 4 times a day. Children 6 years of age and older—50 to 100 mg per day given in divided doses. Children younger than 6 years of age—50 mg per day given in divided doses. For management of allergic reactions:, There are 647 drugs known to interact with trazodone, along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 136 are major, 496 are …, Moderator. Hydroxyzine is an antihistamine (like Benadryl, but a whole lot stronger) with the side effect of causing most people to relax/sleep... It's often used during surgery with anesthesia, and post OP. Trazadone is another med that's used mostly for sleep. So I'd suspect that these are both intended as bedtime meds. Check with your doc ..., Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. phenytoin. trazodone increases levels of phenytoin by unspecified interaction mechanism. , chlordiazePOXIDE hydrOXYzine. Applies to: chlordiazepoxide and Vistaril (hydroxyzine) Using chlordiazePOXIDE together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination., 25 Apr 2022 ... ... hydroxyzine is also prescribed to ... (hydroxyzine hydrochloride) and Vistaril (hydroxyzine pamoate). ... For example, antidepressants like trazodone ..., OBJECTIVE: While trazodone is approved for the treatment of depression, the off-label use of this medication for insomnia has surpassed its usage as an antidepressant. In this systematic review, we examined the evidence for the efficacy and safety of trazodone for insomnia. METHODS: A literature search was conducted using …, Trazodone and hydroxyzine. I experimented with hydroxyzine, but it took around three hours to take effect, providing only a sense of calm without inducing drowsiness. Dissatisfied, I informed my doctor, who then prescribed trazodone. I took it at 9:30 pm, and as of 11:34 pm, I haven't experienced any noticeable effects., The following applies to the ingredients: Trazodone and Escitalopram (found in Lexapro) MONITOR CLOSELY: Concomitant use of agents with serotonergic activity including selective serotonin reuptake inhibitors, tricyclic antidepressants, and other antidepressants may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially …, Trazadone and mirtazapine both made my insomnia even worse. I stayed up like 2 days straight from 100 mg Trazodone and felt really weird. Seroquel wouldn't work unless I took 100- 200mg and then even if I slept 8-10 hours I was still a zombie. Hydroxizine worked for a while., traZODone escitalopram. Applies to: trazodone and Lexapro (escitalopram) Using escitalopram together with traZODone can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive ..., 14-C Urea breath test: Drug information; Abacavir and lamivudine: Drug information; Abacavir, lamivudine, and zidovudine: Drug information; Abacavir: Drug information, Although sedative antidepressants (e.g., trazodone, amitriptyline, mirtazapine) have been used in patients with depression complicated by insomnia, double-blind placebo …, Hydroxyzine made me very groggy. So my doc prescribed Trazodone which works fine with me. To address bedtime anxiety, suggest trying Cognitive Behavioral Therapy - Insomnia and Sleep Hypnotherapy. My experience is, CBT-i helps reduce bedtime anxiety and Sleep Hypnotherapy helps falling asleep quickly and Trazodone helps keeping me …, Summary. Sequenced (stepped) treatment approaches are widely endorsed in the management of depression. Combining antidepressants is a recognised step for those failing to respond to monotherapy. Despite the limited evidence base, this strategy is widely used by clinicians in practice., Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the mouth, stuffy nose, constipation, or change ..., Node 2b: problematic sleep onset–try hydroxyzine, trazodone, or clonidine. If a patient presents with sleep onset difficulties but denies nightmares or disturbed awakenings, hydroxyzine, trazodone, or clonidine may be considered. These are also recommended if the patient had a satisfactory response to prazosin for nightmares and …, hydrOXYzine lurasidone. Applies to: hydroxyzine and Latuda (lurasidone) Using hydrOXYzine together with lurasidone may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems., What’s really needed, many conservationists believe, is a complete reboot to the way the world approaches wildlife protection in Africa. Kafue National Park in the heart of Zambia ..., Mechanisms of action of gabapentin. Gabapentin is an anticonvulsant drug that reduces synaptic transmission by decreasing presynaptic voltage-gated Ca 2+ and Na + channels. 2 – 4 Besides, gabapentin reduces exocytosis and the discharge of neurotransmitter from presynaptic terminals. 5, 6 On the other hand, another line of …, hydrOXYzine lurasidone. Applies to: hydroxyzine and Latuda (lurasidone) Using hydrOXYzine together with lurasidone may increase side effects such as drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems., Hydroxyzine Ibutilide Imipramine Inotuzumab Ozogamicin Itraconazole Ivabradine Ivosidenib Ketoconazole Lefamulin Lenvatinib Leuprolide Levofloxacin Linezolid ... Trazodone Triclabendazole Trifluoperazine Trimethoprim Trimipramine Triptorelin Vandetanib Vardenafil Vemurafenib Venlafaxine Vilanterol Vinflunine ..., Recently out of the blue I'm in a full blown anxiety driven mental breakdown. Doc prescribed hydroxyzine, which does seem to be helping. However, doc really wanted to start me on trazodone to address the issue long term. I'm very hesitant as I'm concerned about side effects. However, my main concern is feeling normal again and I'm not sure I'll ... , Applies to: Klonopin (clonazepam) and hydroxyzine. Using clonazePAM together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of ... , Apr 22, 2020 · The only interaction between trazodone and hydroxyzine is that they both can cause sedation and drowsiness, and so the two may have an additive effect. Yes, that's fine, they just automatically offer the phone call, we can keep messaging here. Understand, so I I put some time like an hour between the Traz and hydroxyzine it will be ok.. , Apr 21, 2017 · Hydroxyzine was found to block peak hERG channel tail currents in a concentration‐dependent manner, with an IC 50 of 0.39 μmol/L at near‐physiological temperature (n = 4; Fig. 1). Inhibitory effects of hydroxyzine were also observed for specific voltage‐gated sodium and calcium cardiac ion channels (Nav1.5 and Cav1.2; Fig. 1). These ... , Hydroxyzine has an average rating of 5.7 out of 10 from a total of 1375 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 36% reported a negative effect. Mirtazapine has an average rating of 6.8 out of 10 from a total of 2023 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 21% reported a negative ... , Applies to: trazodone and Atarax (hydroxyzine) Using traZODone together with hydrOXYzine can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases ...