Methocarbamol and tizanidine

dantrolene, diazepam, metaxalone, methocarbamol, orphenadrine, and tizanidine. Outcomes assessed in the review included improvement in functional outcomes, muscle tension, stiffness, daily living activity, sleep impairment, and pain severity.3 In terms of adverse effects between SMR,

Side effects of methocarbamol include dizziness, drowsiness, and blurry vision. Prescription only. Tizanidine (Zanaflex) is a muscle relaxer used to treat stiff, rigid …Because they cause CNS depression, several skeletal muscle relaxants are on the Beers list, including carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine. 12 These agents are poorly tolerated in patients more than 65 years old due to anticholinergic AEs, sedation, and risk for falls and fractures. 12 ...Bottom Line. Tizanidine relieves muscle spasms but may cause sleepiness, a drop in blood pressure, and sedation. The dosage should be individualized and because it only lasts for a short time in the body, can be taken on an as needed basis. Monitoring of liver enzymes is required. 5.There is insufficient evidence to determine the relative efficacy or safety of cyclobenzaprine, carisoprodol, orphenadrine, tizanidine, metaxalone, methocarbamol, and chlorzoxazone.Drug interactions are reported among 380 peopel who take Tizanidine hydrochloride and Meloxicam. Common interactions among females include drug ineffective and hypertension. Common interactions among males include anxiety and chronic kidney disease.

Three medications have spasticity reduction as their primary indication: baclofen (Lioresal ®), dantrolene (Dantrium ®), and tizanidine (Zanaflex ®). These drugs represent the mainstays of ...Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adults due to risk for sedation and falls. Others (tizanidine, baclofen, dantrolene) may be helpful for neck and back pain, with the most evidence for tizanidine and baclofen. These should be used ...Tizanidine Interactions. There are 608 drugs known to interact with tizanidine, along with 4 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 237 are major, 369 are moderate, and 2 are minor.Muscle relaxers are a group of drugs used to treat musculoskeletal pain, meaning pain involving muscles, bones, joints, and connective tissues like ligaments and tendons. Muscle relaxers are sometimes prescribed to people with osteoarthritis ("wear-and-tear" arthritis) as well as those with lower back pain, neck pain, and other …Methocarbamol is a central-acting muscle relaxant used to treat skeletal muscle spasms and pain related to severe muscle spasm. It is also associated with ...Apr 28, 2022 · Best Answer. It is not so much which is stronger, as much as what the function of the medication is. Methocarbamol is used to treat muslce spams, whereas Zanaflex is used to treat spascity, or ...

Flexeril‚ or cyclobenzaprine‚ is primarily used to relieve muscle pain‚ stiffness‚ and discomfort caused by musculoskeletal conditions. It is commonly prescribed for the following purposes: Muscle spasms: Flexeril is often prescribed to treat muscle spasms associated with injuries‚ sprains‚ strains‚ or other musculoskeletal trauma.Table of contents. Methocarbamol. Cyclobenzaprine. Carisoprodol. Metaxalone. Tizanidine. Baclofen. Oxazepam and diazepam. Chlorzoxazone. …Possible Side Effects and Risks. As with all drugs, muscle relaxers can cause side effects. The one possible side effect common to all muscle relaxers is dizziness and drowsiness, although some cause greater drowsiness than others. Common side effects of muscle relaxants (by drug class) include: Benzodiazepines. Drowsiness.Jun 24, 2019 · Mixing muscle relaxers and alcohol can make the effects of muscle relaxers more intense — and not in a good way. This can lead to potentially dangerous symptoms, such as: increased drowsiness or ...

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Jun 20, 2020 ... The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and ...Cyclobenzaprine should be taken at doses ranging from 5-10 mg three times per day with no more than 30 mg daily, while Tizanidine usually begins with 2-4 mg per day but can increase up to 36 mg as needed. In addition, Cyclobenzaprine remains active longer once ingested due to its much larger half-life (18 hours) than Tizanidine, which in ...Jul 13, 2023 · Store your methocarbamol tablets at room temperature, 68 to 77F (20 to 25C). 6. Response and effectiveness. Methocarbamol starts working in about 30 minutes and its full effects are seen within 2 hours. Methocarbamol is relatively short-acting and needs to be taken three to four times a day as directed by a doctor. 7. Interactions Peer-Reviewed. Muscle relaxers are prescription medications that help regulate muscle contraction (tightening) to reduce pain and discomfort caused by muscle spasms and muscle spasticity (stiffness). Short-term use of muscle relaxers relieves pain caused by tense or spasming muscles and improves daily functioning. 1 Barreto TW, Lin KW.Tizanidine is an FDA-approved drug for managing spasticity. It is a centrally acting alpha-2 receptor agonist. Tizanidine effectively works with spasticity caused by multiple sclerosis‚ an acquired brain injury‚ or a spinal cord injury. It has also been shown to be clinically effective in managing patients suffering from chronic neck and ...Carisoprodol, cyclobenzaprine, metaxalone, methocarbamol, thiocolchicoside, tizanidine, tolperisone, orphenadrine Benzodiazepines To reduce acute muscle spasm commonly associated with muscle injury. These drugs also have a strong sedative action as well as anxiolytic, hypnotic, and anticonvulsant actions Diazepam

Nov 21, 2022 · The other medications listed here may not raise tizanidine levels as much. But you should talk to your healthcare provider before taking them. They can help you weigh the risks and benefits. They might consider lowering your tizanidine dose. Or they may just ask you to watch out for tizanidine side effects. 2. Birth control pills Feb 2, 2024 ... The ultimate decision to transition the patient to methocarbamol and stop taking tizanidine for pain control highlights the importance of ...Methocarbamol, a muscle relaxant with a distinct mechanism of action from tizanidine, was chosen to ensure adequate pain control while minimizing the risk of adverse events. This approach aligns with the principle of individualized care, recognizing the need to tailor treatment strategies to the unique characteristics and tolerances of each patient.Carisoprodol, cyclobenzaprine, metaxalone, methocarbamol, thiocolchicoside, tizanidine, tolperisone, orphenadrine Benzodiazepines To reduce acute muscle spasm commonly associated with muscle injury. These drugs also have a strong sedative action as well as anxiolytic, hypnotic, and anticonvulsant actions DiazepamTizanidine 4 mgs was short acting and I woke up at 3am, like a light switch. Then I was switched to 750mgs Methacarbamol 4 X's a day and I'm thinking if ...As nouns the difference between methocarbamol and tizanidine. is that methocarbamol is a central muscle relaxant, the carbamate of guaifenesin, used to treat skeletal muscle spasms while tizanidine is a particular drug used as a muscle relaxant.Reproductive studies for methocarbamol haven’t been done in animals. But there have been reports of abnormalities in developing babies when exposed to methocarbamol during pregnancy. Similar to carisoprodol, it’s important that you and your healthcare provider weigh methocarbamol’s risks versus benefits before taking it. …Non-benzodiazepines include a variety of drugs that can act at the brain stem or spinal cord level. Examples include carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, tizanidine, and orphenadrine. All antispasmodic agents can cause significant drowsiness, dizziness, confusion, nausea, and vomiting.Dr prescribed tizanidine for muscle spasms due to chronic back issues following L5S1 fusion in 2016/2017. My only complaint about this medication is that it makes me drowsy during the day.. Dr switched me to methocarbamol to eliminate drowsiness. First we tried 500mg, it was not effective. Then we tried 750mg, and its still not effective.Are you struggling to secure a loan from a small bank? If yes, then according to the Biz2Credit Lending Index January 2020 report, reach out to a big bank. Are you struggling to se...Comparing Robaxin vs Tizanidine. Robaxin (methocarbamol) Tizanidine. Prescription only. Prescribed for Muscle Spasm, Tetanus. Robaxin may also be used for purposes not listed in this medication guide. Prescription only. Tizanidine relieves muscle spasms but may cause sleepiness, a drop in blood pressure, and sedation.There is insufficient evidence to determine the relative efficacy or safety of cyclobenzaprine, carisoprodol, orphenadrine, tizanidine, metaxalone, methocarbamol, and chlorzoxazone. Dantrolene, and to a lesser degree chlorzoxazone, have been associated with rare serious hepatotoxicity.

As nouns the difference between methocarbamol and tizanidine. is that methocarbamol is a central muscle relaxant, the carbamate of guaifenesin, used to treat skeletal muscle spasms while tizanidine is a particular drug used as a muscle relaxant.

4 days ago · Viloxazine. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adagrasib. Alfentanil. Alprazolam. Amantadine. Benzhydrocodone. Methocarbamol is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Methocarbamol injection is sometimes used in the treatment of tetanus, (lockjaw) which causes painful tightening of the muscles. Warnings. You should not use this medication if you are allergic to methocarbamol.The workplace isn’t just the office anymore—so Microsoft Office needs to catch up. The shift to remote work has not been kind to Microsoft—its productivity software is literally na...Methocarbamol (Robaxin®). Orphenadrine (Norflex®). Antispastic skeletal muscle relaxants that providers can currently prescribe in the U.S. include: Baclofen (Lioresal®). Dantrolene (Dantrium®). Two skeletal muscle relaxants have both antispastic and antispasmodic effects. They include: Tizanidine (Zanaflex®). Diazepam (Valium®). Tizanidine Interactions. There are 608 drugs known to interact with tizanidine, along with 4 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 237 are major, 369 are moderate, and 2 are minor. Dec 17, 2008 ... ... methocarbamol (Robaxin), orphenadrine, and tizanidine. (Zanaflex). There is fair evidence that baclofen, tizanidine, and dantrolene are ...Tizanidine is an FDA-approved drug for managing spasticity. It is a centrally acting alpha-2 receptor agonist. Tizanidine effectively works with spasticity caused by multiple sclerosis, an acquired brain injury, or a spinal cord injury. It has also been shown to be clinically effective in managing patients suffering from chronic neck and lumbosacral … In general, antispasticity agents and antispasmodics are not interchangeable and should not be substituted for one another. However, some muscle relaxants, such as tizanadine and diazepam, carry indications approved by the Food and Drug Administration (FDA) for both conditions ( Figure 1 ).

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Carisoprodol, cyclobenzaprine, metaxalone, methocarbamol, thiocolchicoside, tizanidine, tolperisone, orphenadrine Benzodiazepines To reduce acute muscle spasm commonly associated with muscle injury. These drugs also have a strong sedative action as well as anxiolytic, hypnotic, and anticonvulsant actions Diazepam Side effects of methocarbamol include dizziness, drowsiness, and blurry vision. Prescription only. Tizanidine (Zanaflex) is a muscle relaxer used to treat stiff, rigid …Background: Pain management is a high priority for patients with rheumatoid arthritis (RA). Muscle relaxants include drugs that reduce muscle spasm (for example benzodiazepines such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and non-benzodiazepines such as metaxalone (Skelaxin) or a combination of paracetamol …There is insufficient evidence to determine the relative efficacy or safety of cyclobenzaprine, carisoprodol, orphenadrine, tizanidine, metaxalone, methocarbamol, and chlorzoxazone. Dantrolene, and to a lesser degree chlorzoxazone, …Dosage and Administration. The recommended starting dose of tizanidine is 2 mg. Treatment can be repeated at 6 to 8 h intervals as needed. The dose of tizanidine can be gradually increased by 2–4 mg per dose, with intervals of 1–4 days between each increase, until a satisfactory reduction in muscle tone is achieved.More about Tizanidine. Ratings & Reviews. Cyclobenzaprine has an average rating of 5.9 out of 10 from a total of 617 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 31% reported a negative effect. Tizanidine has an average rating of 6.1 out of 10 from a total of 377 ratings on Drugs.com. 48% of reviewers reported a ...Dosage and Administration. The recommended starting dose of tizanidine is 2 mg. Treatment can be repeated at 6 to 8 h intervals as needed. The dose of tizanidine can be gradually increased by 2–4 mg per dose, with intervals of 1–4 days between each increase, until a satisfactory reduction in muscle tone is achieved.metaxalone Skelaxin methocarbamol Robaxin, Robaxin-750 orphenadrine No brand name currently marketed tizanidine Zanaflex Antipsychotics aripiprazole Abilify, Abilify Maintena, AristadaMethocarbamol is Robaxin,I take 2/ 750mg a day. Tizanidine is Zanaflex,they took me off it 2 years ago because it can cause liver damage.Both are muscle relaxers.I could get a really good night sleep with the Zanaflex.They only had me on 4mg.As long as they do blood work on liver function you may be alright, but I have not heard. of Doctors ...Methocarbamol isn’t a narcotic. It’s a central nervous system (CNS) depressant and muscle relaxant used to treat muscle spasms, tension, and pain. It may be mistaken for a narcotic due to side ...Meloxicam (Mobic) is a prescription-only nonsteroidal anti-inflammatory drug (NSAID). Several medications and substances interact with it. Meloxicam interacts with blood thinners, some antidepressants, and certain blood pressure medications. Lithium (Lithobid), methotrexate (Trexall), and alcohol also interact with it.Tizanidine is an FDA-approved drug for managing spasticity. It is a centrally acting alpha-2 receptor agonist. Tizanidine effectively works with spasticity caused by multiple sclerosis‚ an acquired brain injury‚ or a spinal cord injury. It has also been shown to be clinically effective in managing patients suffering from chronic neck and ... ….

These signals involved the four most used SMRs—cyclobenzaprine, tizanidine, baclofen, and methocarbamol. Our findings may provide important targets to guide hypothesis generation and prioritize future etiologic investigations into higher-order SMR interactions and risk for unintentional traumatic injury.Your credit score plays an important role in the rates you’ll pay for car insurance and home insurance — and your score can even influence your life insu... Get top content in our ...More about Flexeril ( cyclobenzaprine ) Ratings & Reviews. Tizanidine has an average rating of 6.1 out of 10 from a total of 377 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 30% reported a negative effect. Flexeril has an average rating of 6.0 out of 10 from a total of 237 ratings on Drugs.com. 47% of reviewers ...More about Tizanidine. Ratings & Reviews. Cyclobenzaprine has an average rating of 5.9 out of 10 from a total of 617 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 31% reported a negative effect. Tizanidine has an average rating of 6.1 out of 10 from a total of 377 ratings on Drugs.com. 48% of reviewers reported a ...Lower-cost generic is available. Ratings & Reviews. Baclofen has an average rating of 7.0 out of 10 from a total of 434 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 24% reported a negative effect. Methocarbamol has an average rating of 6.3 out of 10 from a total of 297 ratings on Drugs.com. 51% of reviewers reported ...Baclofen and tizanidine are the only two drugs FDA approved for muscle spasticity. Often times the selection will depend on the mechanism of action/Side effect profile in the underlying ailment. For instance cyclobenzaprine may be more appropriate in somebody with muscle issues and some type of neuropathy. Reply. namuu9798.Muscle relaxers are a group of drugs used to treat musculoskeletal pain, meaning pain involving muscles, bones, joints, and connective tissues like ligaments and tendons. Muscle relaxers are sometimes prescribed to people with osteoarthritis ("wear-and-tear" arthritis) as well as those with lower back pain, neck pain, and other …If you are looking for the next meme stock champion, here are three picks that are not AMC, Bed Bath & Beyond or GameStop. If you're looking to get in on the action, keep an eye on...More about Metaxalone. Ratings & Reviews. Cyclobenzaprine has an average rating of 5.9 out of 10 from a total of 617 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 31% reported a negative effect. Metaxalone has an average rating of 7.2 out of 10 from a total of 127 ratings on Drugs.com. 60% of reviewers reported a ... Methocarbamol and tizanidine, Non-benzodiazepines include a variety of drugs that can act at the brain stem or spinal cord level. Examples include carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, tizanidine, and orphenadrine. All antispasmodic agents can cause significant drowsiness, dizziness, confusion, nausea, and vomiting., There's a constant flow of "email is/is not broken" articles across the internet, but most of them miss the point. Email as a system is not broken, but we, through our email behavi..., Methocarbamol is a centrally acting muscle relaxant, which doctors primarily use for treating musculoskeletal pain. Possible side effects may include lightheadedness, drowsiness, and dizziness ..., Tizanidine is a centrally acting alpha-2 agonist with muscle-relaxant, sedative, and anxiolytic properties. It has been used to treat pain associated with muscle spasms, and myofascial and neuropathic pain [34-36]. In 2016, Yazicioğlu et al. studied tizanidine use after inguinal hernia repair in a randomized double-blind study. The primary ..., Tizanidine 4 mgs was short acting and I woke up at 3am, like a light switch. Then I was switched to 750mgs Methacarbamol 4 X's a day and I'm thinking if ..., Methocarbamol is a central-acting muscle relaxant used to treat skeletal muscle spasms and pain related to severe muscle spasm. It is also associated with ..., Tizanidine is generally started at a single nightly dose and titrated upwards adding multiple daytime doses. This is a risk, because this drug induces drowsiness, impacting patients during the day, and it requires a difficult adherence regimen. 35 Halpern et al. conducted a study including 2840 patients., Methocarbamol (robaxin) is structurally similar to mephenisin, and while the mechanism of action is unknown, it is thought to cause inhibition of carbonic anhydrase and may …, Background: Pain management is a high priority for patients with rheumatoid arthritis (RA). Muscle relaxants include drugs that reduce muscle spasm (for example benzodiazepines such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and non-benzodiazepines such as metaxalone (Skelaxin) or a combination of paracetamol …, Tizanidine is used to help relax certain muscles in your body. It relieves spasms, cramping, and tightness of the muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine. Tizanidine does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in …, A passenger on SeaDream Yacht Club's SeaDream 1 has tested positive for COVID on a preliminary basis. The first cruise vessel to resume sailing in the Caribbean is in the midst of ..., Peer-Reviewed. Muscle relaxers are prescription medications that help regulate muscle contraction (tightening) to reduce pain and discomfort caused by muscle spasms and muscle spasticity (stiffness). Short-term use of muscle relaxers relieves pain caused by tense or spasming muscles and improves daily functioning. 1 Barreto TW, Lin KW., Lower-cost generic is available. Ratings & Reviews. Methocarbamol has an average rating of 6.3 out of 10 from a total of 297 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 30% reported a negative effect. Zanaflex has an average rating of 7.5 out of 10 from a total of 117 ratings on Drugs.com. 67% of reviewers reported ... , The primary indications for cyclobenzaprine, metaxolone, methocarbamol, and carisoprodol are acute painful musculoskeletal conditions. 16 Baclofen and tizanidine are indicated for spasticity associated with UMN disorders, but are frequently used off-label for painful musculoskeletal conditions. Diazepam is indicated for UMN muscle spasticity ..., More about Tizanidine. Ratings & Reviews. Cyclobenzaprine has an average rating of 5.9 out of 10 from a total of 617 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 31% reported a negative effect. Tizanidine has an average rating of 6.1 out of 10 from a total of 377 ratings on Drugs.com. 48% of reviewers reported a ..., Jun 24, 2019 · Mixing muscle relaxers and alcohol can make the effects of muscle relaxers more intense — and not in a good way. This can lead to potentially dangerous symptoms, such as: increased drowsiness or ... , There are 342 drugs known to interact with methocarbamol, along with 2 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 28 are ... cyclobenzaprine, baclofen, tizanidine, diazepam, Flexeril, Valium, Robaxin, chlorpromazine, Soma, Thorazine. Related Stories., Methocarbamol (Robaxin®, others). FDA Approved ... Tizanidine (Zanaflex®, others). Approved 1996 ... Regarding the anti-spasticity agents (baclofen, dantrolene and ..., Feb 25, 2020 · Q: Which muscle relaxer is the strongest? There are several muscle relaxers, or skeletal muscle relaxants. They include cyclobenzaprine (Flexeril), methocarbamol (Robaxin), and tizanidine (Zanaflex), among others. According to the American Academy of Family Physicians, there is no clear evidence that one is better or stronger than another. , Muscle relaxants are used to treat two different conditions: (1) spasticity from upper motor neuron syndromes as occurs in multiple sclerosis and (2) muscular pain or spasms from peripheral musculoskeletal diseases or injury such as low back pain. The muscle relaxants in current use have variable mechanisms of action, efficacy and adverse effects., methocarbamol, chlorzoxazone, baclofen, or dantrolene compared to placebo in patients with musculoskeletal conditions. There is insufficient evidence to determine the relative efficacy or safety of cyclobenzaprine, carisoprodol, orphenadrine, tizanidine, metaxalone, methocarbamol, and chlorzoxazone. Dantrolene, and to a lesser degree ... , The primary indications for cyclobenzaprine, metaxolone, methocarbamol, and carisoprodol are acute painful musculoskeletal conditions. 16 Baclofen and tizanidine are indicated for spasticity associated with UMN disorders, but are frequently used off-label for painful musculoskeletal conditions. Diazepam is indicated for UMN muscle spasticity ... , Tizanidine. Methocarbamol. A cannabis extract containing dronabinol and cannabidiol (trade name Sativex®). Most muscle relaxant preparations are available as tablets, capsules, or liquids. Baclofen is also available as an injection into the back (an intrathecal injection)., In the United States, carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine have been approved by the US Food and Drug Administration (FDA) for the treatment of acute musculoskeletal conditions. Other muscle relaxants, such as baclofen, tizanidine, and dantrolene, are FDA approved for …, No, Methocarbamol and Tizanidine are not the same. While both are prescription medications only used as muscle relaxants, they have different mechanisms of action, chemical structures, and potential side effects. Acts as a muscle relaxant, affecting the central nervous system and inhibiting nerve impulses or pain signals., Background: Pain management is a high priority for patients with rheumatoid arthritis (RA). Muscle relaxants include drugs that reduce muscle spasm (for example benzodiazepines such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and non-benzodiazepines such as metaxalone (Skelaxin) or a combination of paracetamol …, The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. Methocarbamol and metaxalone are less sedating, although effectiveness evidence is limited. Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants. Reply., The FDA has not approved tizanidine to treat neck or back pain. For multiple sclerosis or cerebral palsy, tizanidine tends to have fewer side effects than Baclofen. But either medication may not make much difference in new low back pain when compared with ibuprofen alone. Tizanidine is not a first choice for new neck or back muscle pain. 6 ..., Muscle spasms and related pain can be highly debilitating, affecting our daily activities and overall quality of life. Methocarbamol and cyclobenzaprine are commonly prescribed medications for muscle relaxation. While both drugs aim to alleviate muscle discomfort, they differ in various aspects, including their mechanisms of action, uses, side effects, …, Tizanidine is a short-acting muscle relaxant and is used to treat spasticity. Learn about side effects, interactions and indications. ... methocarbamol, diazepam, Flexeril, Soma How should I take tizanidine? Take tizanidine exactly as it …, Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adults due to risk for sedation and falls. Others (tizanidine, baclofen, dantrolene) may be helpful for neck and back pain, with the most evidence for tizanidine and baclofen. These should be used ..., Methocarbamol (Robaxin®). Orphenadrine (Norflex®). Antispastic skeletal muscle relaxants that providers can currently prescribe in the U.S. include: Baclofen (Lioresal®). Dantrolene (Dantrium®). Two skeletal muscle relaxants have both antispastic and antispasmodic effects. They include: Tizanidine (Zanaflex®). Diazepam (Valium®)., Furthermore, Tizanidine has a relatively short duration of action, with its effects lasting for about 3-6 hours. In contrast, Cyclobenzaprine has a longer duration of action, with its effects typically lasting for 12-24 hours. This difference in duration may influence the dosing frequency and overall treatment approach for patients.