Metamucil side effects mayo clinic

Sep 30, 2019 · The Mayo Clinic researchers found between 2.3 and 3.4 percent of Americans with moderate kidney disease took supplements considered as “especially risky” by the National Kidney Foundation. Other supplements may also be harmful for people with kidney disease, the researchers caution, since there is little research in this area and ...

Changes in the color or temperature of the skin. Severe pain on your skin. Talk to your healthcare team if you take warfarin and have these symptoms: Bleeding from a cut or the nose or gums that lasts less than 5 minutes. For example, if your gums bleed after brushing your teeth. Bleeding between menstrual periods.Although studies show that Metamucil may be beneficial for weight loss, there are a few side effects to consider. In particular, it may cause mild digestive issues for some people, including gas ...Check with your doctor right away if you have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or a skin rash, sores or ulcers on the skin, or fever or chills with this medicine. Serious lung or breathing problems (eg, interstitial pneumonitis) may occur after you receive this medicine.For safe and effective use of your laxative: Follow your doctor's instructions if this laxative was prescribed. Follow the manufacturer's package directions if you are treating yourself. With all kinds of laxatives, at least 6 to 8 glasses (8 ounces each) of liquids should be taken each day. This will help make the stool softer.In some cases of mild antibiotic-associated diarrhea, your doctor may recommend anti-diarrheal medications, such as loperamide (Imodium A-D). But check with your doctor before taking anti-diarrheal medications because they can interfere with your body's ability to eliminate toxins and lead to serious complications.The Mayo Clinic researchers found between 2.3 and 3.4 percent of Americans with moderate kidney disease took supplements considered as “especially risky” by the National Kidney Foundation. Other supplements may also be harmful for people with kidney disease, the researchers caution, since there is little research in this area and ...numbness or tingling in the face, arms, or legs. pain in the stomach, side, or abdomen, possibly radiating to the back. pain or swelling in the arms or legs without any injury. pain, tension, and weakness upon walking that subsides during periods of rest. pinpoint red spots on the skin.

Gastroparesis can interfere with normal digestion, cause nausea, vomiting and abdominal pain. It can also cause problems with blood sugar levels and nutrition. Although there's no cure for gastroparesis, changes to your diet, along with medication, can offer some relief.Descriptions. Colestipol is used to lower high cholesterol levels in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels. Colestipol works by attaching to certain substances in the intestine.large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. red skin lesions, often with a purple center sore. red, irritated eyes. sore throat. sores, ulcers, or white spots in the mouth or on the lips. Some side effects may occur that usually do not need medical attention.puffiness or swelling of the eyelids or around the eyes, face, lips or tongue. slow or irregular heartbeat. unusual tiredness or weakness. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.stomach pain, nausea, or vomiting; trouble swallowing; or. a sudden change in bowel habits lasting longer than 2 weeks. This medicine may contain sugar, …Metamucil is well tolerated by most people. However, side effects may occur, such as: gas; nausea; stomach pain; bloating; To decrease your risk of discomfort, start with a lower dose and increase ...The dosage is higher for Metamucil than Benefiber. The recommended dose of Benefiber for adults is two teaspoons (tsp) dissolved in liquid. The recommended dose for Metamucil Orange Smooth for ...red skin lesions, often with a purple center. red, irritated eyes. sore throat. sores, ulcers, or white spots in the mouth or on the lips. sweating. tightness of the chest. unusual tiredness or weakness. Some side effects may occur that usually do not need medical attention.

puffiness or swelling of the eyelids or around the eyes, face, lips or tongue. slow or irregular heartbeat. unusual tiredness or weakness. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.unusual tiredness or weakness. vomiting. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.swelling of the breasts or breast soreness in both females and males. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.Descriptions. Cholestyramine is used to lower high cholesterol levels in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels. Cholestyramine is also used to remove substances called bile acids from your body.Descriptions. Hydralazine is used to treat high blood pressure (hypertension). It is also used to control high blood pressure in a mother during pregnancy (pre-eclampsia or eclampsia) or in emergency situations when blood pressure is extremely high (hypertensive crisis). High blood pressure adds to the workload of the heart and arteries.

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Desloratadine is an antihistamine. It is used to relieve the symptoms of hay fever and hives of the skin. Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Also, in some persons histamine can close up the bronchial ...Oxybutynin belongs to the group of medicines called antispasmodics. It helps decrease muscle spasms of the bladder and the frequent urge to urinate caused by these spasms. Oxybutynin extended-release tablets is also used to treat children 6 years of age and older who have an overactive bladder caused by a certain nerve disorder (eg, spina bifida).red skin lesions, often with a purple center. red, irritated eyes. seizures. stomach pain. unpleasant breath odor. vomiting of blood. yellow eyes or skin. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.Colonoscopy prep: make it easier. Among the many discomforts of having a colonoscopy, people often say that the prep work before is the worst part. Below are a few tips can help make the process easier: Two days beforehand. Start eating a low-fiber diet. Avoid raw fruits and vegetables, whole grains, and nuts and seeds. The day before.Descriptions. Dexmethylphenidate is used to treat attention deficit hyperactivity disorder (ADHD). It belongs to the group of medicines called central nervous system (CNS) stimulants. Dexmethylphenidate increases attention and decreases restlessness in patients who are hyperactive, cannot concentrate, or are easily distracted.

Feb. 20, 2018. Normal enterohepatic circulation of bile acids. Excess bile acids entering the colon can cause the classic signs and symptoms of bile acid malabsorption (BAM), including watery stool, urgency and fecal incontinence. Although BAM has been associated with diarrhea for nearly 50 years, it remains an underrecognized and ...pain or burning while urinating. painful or difficult urination. pale skin. pinpoint red spots on the skin. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. rash. red, irritated eyes. redness, soreness, or itching skin. shortness of breath.Belching. bloating. diarrhea. dizziness. headache. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.continuing ringing or buzzing or other unexplained noise in the ears. hearing loss. heartburn. indigestion. lack or loss of strength. stomach discomfort or upset. vomiting. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.These could be symptoms of serotonin syndrome. This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting.stomach discomfort, upset, or pain. trouble sleeping. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness. swollen joints. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects.Abnormal fat deposits on the face, neck, and trunk. acne. dry scalp. lightening of normal skin color. red face. reddish purple lines on the arms, face, legs, trunk, or groin. swelling of the stomach area. thinning of the scalp hair. Other side effects not listed may also occur in some patients.Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.rough, scratchy sound to voice. sensation of spinning. tightness in the throat. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Mayo Clinic scientists say that if animal trials hold up in humans, these drugs have the potential to revolutionize modern medicine. Earlier this week, doctors at the Mayo Clinic a...

Simethicone is used to relieve the painful symptoms of too much gas in the stomach and intestines. Simethicone may also be used for other conditions as determined by your doctor. Simethicone is available without a prescription. This product is available in the following dosage forms: Capsule, Liquid Filled.Abnormal fat deposits on the face, neck, and trunk. acne. dry scalp. lightening of normal skin color. red face. reddish purple lines on the arms, face, legs, trunk, or groin. swelling of the stomach area. thinning of the scalp hair. Other side effects not listed may also occur in some patients.Dietary fiber — found mainly in fruits, vegetables, whole grains and legumes — is probably best known for its ability to prevent or relieve constipation. But foods containing fiber can provide other health benefits as well, such as helping to maintain a healthy weight and lowering your risk of diabetes, heart disease and some types of cancer.These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. ... From Mayo Clinic to your inbox Sign up for free and stay up to date on research advancements, health tips, current health topics, and ...May 12, 2023 · Side effects — which might be reduced if you take the medication at bedtime — can include drowsiness, blurred vision, dizziness and dry mouth. SSRI antidepressants. Selective serotonin reuptake inhibitor (SSRI) antidepressants, such as fluoxetine (Prozac) or paroxetine (Paxil), may help if you are depressed and have pain and constipation. numbness or tingling in the face, arms, or legs. rapid, shallow breathing. severe headache. stomach pain or tenderness. swelling of the feet or lower legs. thickening of bronchial secretions. trouble speaking or walking. vomiting. Some side effects may occur that usually do not need medical attention.cough or hoarseness. decreased appetite. diarrhea. fast or shallow breathing. fever or chills. general feeling of discomfort. lower back or side pain. muscle pain or cramping. painful or difficult urination.Response/effectiveness. Interactions. 1. How it works. Metamucil is a brand (trade) name for a powdered form of psyllium husk, which is a type of soluble fiber derived from the seed husks of Plantago ovata, a type of plant. Metamucil may be given to relieve constipation or to lower cholesterol.

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muscle cramps, pains, or stiffness. shakiness in the legs, arms, hands, or feet. stomach discomfort or upset. sudden sweating. swollen joints. trembling or shaking of the hands or feet. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Also tell your doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. If you or your caregiver notice any of these side effects, tell your doctor right away.Simethicone is used to relieve the painful symptoms of too much gas in the stomach and intestines. Simethicone may also be used for other conditions as determined by your doctor. Simethicone is available without a prescription. This product is available in the following dosage forms: Capsule, Liquid Filled.Metamucil is a fiber supplement used for constipation and other conditions. Learn about the common side effects, such as gas and bloating, and the serious ones, such as bowel obstruction, and how to prevent them.puffiness or swelling of the eyelids or around the eyes, face, lips or tongue. slow or irregular heartbeat. unusual tiredness or weakness. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.Causes. The veins around the anus tend to stretch under pressure and may bulge or swell. Hemorrhoids can develop from increased pressure in the lower rectum due to: Straining during bowel movements. Sitting for long periods of time, especially on the toilet. Having chronic diarrhea or constipation. Being obese.Vitamin D is a nutrient your body needs for building and maintaining healthy bones. That's because your body can only absorb calcium, the primary component of bone, when vitamin D is present. Vitamin D also regulates many other cellular functions in your body. Its anti-inflammatory, antioxidant and neuroprotective properties support immune ...Causes. The veins around the anus tend to stretch under pressure and may bulge or swell. Hemorrhoids can develop from increased pressure in the lower rectum due to: Straining during bowel movements. Sitting for long periods of time, especially on the toilet. Having chronic diarrhea or constipation. Being obese.Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Portions of this document last updated: Feb. 01, 2024Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. Itchiness. Headache. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. There is also concern that milk thistle might affect estrogen levels.sores, welts, or blisters. stomach cramps. swelling, stiffness, redness, or warmth around many joints. swollen lymph glands. vision loss. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.May 22, 2014. Puborectalis muscle at rest and during defecation. As many as 50 percent of people with chronic constipation have pelvic floor dysfunction (PFD) — impaired relaxation and coordination of pelvic floor and abdominal muscles during evacuation. Straining, hard or thin stools, and a feeling of incomplete elimination are common signs ... ….

PSYLLIUM (SIL i yum) may support digestion and heart health. It works by increasing the bulk of your stool. This increases pressure, which helps the muscles in your intestine move stool. It also reduces the amount of cholesterol your body absorbs from food. This medicine may be used for other purposes; ask your health care provider or ...Aug 31, 2023 · Response/effectiveness. Interactions. 1. How it works. Metamucil is a brand (trade) name for a powdered form of psyllium husk, which is a type of soluble fiber derived from the seed husks of Plantago ovata, a type of plant. Metamucil may be given to relieve constipation or to lower cholesterol. unusual tiredness or weakness. vomiting. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.Descriptions. Zolpidem is used to treat insomnia (trouble sleeping). It belongs to the group of medicines called central nervous system (CNS) depressants, which slows down the nervous system. Zolpidem will help you get to sleep faster and sleep throughout the night. In most cases, sleep medicines should only be used for short periods of time ...nervousness. shakiness. stomach pain. unusual tiredness. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Precautions.Amlodipine is used alone or together with other medicines to treat hypertension (high blood pressure). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke ...Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause extreme muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low. Only a few cases of rhabdomyolysis occur per million people taking statins.Trimethoprim may cause blood problems. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Therefore, you should be careful when using regular toothbrushes, dental floss, and toothpicks. Dental work should be delayed until your blood counts have returned to normal.Feb. 20, 2018. Normal enterohepatic circulation of bile acids. Excess bile acids entering the colon can cause the classic signs and symptoms of bile acid malabsorption (BAM), including watery stool, urgency and fecal incontinence. Although BAM has been associated with diarrhea for nearly 50 years, it remains an underrecognized and ...weight gain (rapid) of more than 5 pounds (2 pounds in children) Less common. Chest pain. shortness of breath. Check with your doctor as soon as possible if any of the following side effects occur: More common. Bloating. flushing or redness of skin. swelling of feet or lower legs. Metamucil side effects mayo clinic, unconscious. unpleasant breath odor. unusual bleeding or bruising. unusual tiredness or weakness. unusual weight loss. vomiting of blood. yellow eyes or skin. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional., Serious allergic reactions, including angioedema may occur while you are using this medicine. Tell your doctor right away if you have a rash, itching skin, difficulty with breathing or swallowing, hives, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, nausea, reddening of the skin, especially around the ears, swelling of the eyes, face ..., lack or loss of strength. loss of sense of smell. red irritated eyes. red skin lesions, often with a purple center. redness or other discoloration of the skin. severe sunburn. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional., numbness or tingling in the face, arms, or legs. pain in the stomach, side, or abdomen, possibly radiating to the back. pain or swelling in the arms or legs without any injury. pain, tension, and weakness upon walking that subsides during periods of rest. pinpoint red spots on the skin., Answer From Sahil Khanna, M.B.B.S., M.S. Certain medicines and dietary supplements can irritate the lining of the tube that connects the mouth to the stomach, called the esophagus. This can cause heartburn pain that is like the heartburn of gastroesophageal reflux disease, often called GERD for short. Other medicines can make GERD worse., pale skin at the injection site. runny nose, sneezing. sore throat. unexplained weight loss. Rare. Burning, dry, or itching eyes. discharge or excessive tearing. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. Other side effects not listed may also occur in some patients., Child Life Specialists (CLS) usually work in a hospital setting with children of all ages, providing support and assistance to families during the child's hospitalization. Students..., Serious allergic reactions, including angioedema may occur while you are using this medicine. Tell your doctor right away if you have a rash, itching skin, difficulty with breathing or swallowing, hives, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, nausea, reddening of the skin, especially around the ears, swelling of the eyes, face ..., numbness or tingling of face, hands, or feet. pain, tenderness, or swelling of foot or leg. painful or difficult urination. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. redness and soreness of the eyes. redness of the face, neck, arms, and occasionally, upper chest. skin rash., painful or difficult urination. pains in the stomach, side, or abdomen, possibly radiating to the back. pinpoint red or purple spots on the skin. pounding in the ears. seizures. severe and continuing nausea. severe sunburn. shakiness in the legs, arms, hands, or feet., Apr 1, 2024 · Descriptions. Colestipol is used to lower high cholesterol levels in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels. Colestipol works by attaching to certain substances in the intestine. , Mar 1, 2024 · Nitrofurantoin is used to treat urinary tract infections. This medicine is an antibiotic. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: , Descriptions. Colestipol is used to lower high cholesterol levels in the blood. This may help prevent medical problems caused by cholesterol clogging the blood vessels. Colestipol works by attaching to certain substances in the intestine., Check with your doctor right away if you have chest pain or discomfort, dizziness, headache, nausea or vomiting, pain or discomfort in the arms, jaw, back, or neck, sweating, trouble breathing, or unusual bleeding or bruising. This medicine may cause a tear (perforation) in your stomach or bowels., Methimazole is used to treat hyperthyroidism, a condition where the thyroid gland produces too much thyroid hormone. It is also used before thyroid surgery or radioactive iodine treatment. Methimazole is an antithyroid medicine. It works by making it harder for the body to make thyroid hormone. This medicine is available only with your doctor's ..., dry mouth. loss of elasticity. loss of normal skin markings. raised, dark red, and wart-like spots on the skin, especially when used on the face. shininess. Incidence not known. Burning and itching of the skin with pinhead-sized red blisters. increased hair growth on the forehead, back, arms, and legs., sores, welts, or blisters. stomach cramps. swelling, stiffness, redness, or warmth around many joints. swollen lymph glands. vision loss. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine., However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. Bloating. Stomach cramps. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor., Allow the minoxidil to completely dry for 2 to 4 hours after applying it, including before going to bed. Minoxidil can stain clothing, hats, or bed linen if your hair or scalp is not fully dry after using the medicine. Avoid transferring the medicine while wet to other parts of the body., lightheadedness. loss of heat from the body. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. red skin lesions, often with a purple center. red, irritated eyes. scaly skin. severe stomach pain. tightness in the chest. unpleasant breath odor., Incidence not known. Large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine., Check with your doctor right away if you have dark urine, clay-colored stools, stomach pain, or yellow eyes or skin. These maybe symptoms of a serious liver problem. Ciprofloxacin may lower the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily., Tests. To help confirm a diagnosis of microscopic colitis, you may have one or more of the following tests and procedures: Colonoscopy and biopsies. This exam allows your healthcare professional to view your entire colon using a thin, flexible, lighted tube with an attached camera, called a colonoscope. The camera sends pictures of your rectum ..., Numerous studies point to the significance of a high-fiber diet in promoting positive short- and long-term health outcomes. ( 1) Metamucil is a commonly-used fiber supplement that may be helpful for reaching daily fiber intake goals and improving important factors of health. These include heart health, digestion, appetite, and blood sugar., irritation. joint pain, stiffness, or swelling. redness of the skin. swelling of the eyelids, face, lips, hands, or feet. tightness in the chest. trouble breathing or swallowing. unusual drowsiness, tiredness, weakness, or feeling of sluggishness. Some side effects may occur that usually do not need medical attention., Antibiotic therapy. For most people, the initial way to treat bacterial overgrowth is with antibiotics. Doctors may start this treatment if your symptoms and medical history strongly suggest this is the cause, even when test results are inconclusive or without any testing at all. Testing may be performed if antibiotic treatment is not effective., Check with your doctor right away if you have lower back or side pain, decreased frequency or amount of urine, bloody urine, increased thirst, loss of appetite, nausea, vomiting, unusual tiredness or weakness, swelling of the face, fingers, or lower legs, weight gain, or trouble breathing., Introduction. Antidepressants can cause unpleasant side effects. Signs and symptoms such as nausea, weight gain or sleep problems can be common initially. For many people, these improve within weeks of starting an antidepressant. In some cases, however, antidepressants cause side effects that don't go away. , Potential side effects of cortisone shots increase with larger doses and more frequent use. Side effects can include: Cartilage damage. Death of nearby bone. Joint infection. Nerve damage. Short-term facial flushing. Short-term flare of pain, swelling and irritation in the joint. Short-term increase in blood sugar., Apr 11, 2024 · Brexpiprazole (Rexulti) is a kind of medicine called an atypical antipsychotic. The FDA approved brexpiprazole for treating agitation linked to dementia due to Alzheimer's disease. The medicine is taken as a pill once a day. The label for brexpiprazole carries a severe warning. , Dizziness and drowsiness are common side effects of gabapentin. Some other possible side effects include weight gain and trouble with movement. Some gabapentin side effects, such as feeling drowsy, are more likely to occur when you start taking the medicine. These side effects may go away as your body adjusts. Avoid driving, operating machinery ..., However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. Bloating. Stomach cramps. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor., Within 2 days of starting Metamucil, I began having muscle pain throughout my whole body. I could barely use my hands because of the pain in my forearms and hands. My feet and legs began hurting, it hurt to walk. Stopped the Metamucil for a 2 weeks as suggested by my primary doctor. Pain began to ease off, but constipation returned.