Hydroxyzine and trazodone

I told my primary care doctor my sleeping was still interrupted for various reasons in the night. Hydroxyzine is also a new medication I just started a few days ago. But my PC doctor prescribed me Trazadone to help me sleep at night. I am reluctant to take this because they say their is an interraction between them related to heart issues.

clonazePAM hydrOXYzine. Applies to: Klonopin (clonazepam) and hydroxyzine. Using clonazePAM together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.Drug-drug interaction. This is when a medication reacts with one or more other drugs. For example, taking a cough medicine ( antitussive) and a drug to help you sleep (sedative) could cause the ...Trazodone is a prescription drug used to treat depression and sleep disorders like insomnia.When using trazodone for sleep, the drug is given at low doses—typically between 25 to 100 milligram (mg)—which reduces the risk of drug tolerance and daytime sleepiness. For some people, even lower doses may prove …First choices for difficulty initiating sleep include hydroxyzine and trazodone. If significant non-sleep PTSD symptoms remain, an SSRI should be tried, followed by a second SSRI or venlafaxine as a third step. Second generation antipsychotics can be considered, particularly for SSRI augmentation when PTSD-associated psychotic symptoms are ...Applies to: Klonopin (clonazepam) and hydroxyzine. Using clonazePAM together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the …

Latuda Interactions. There are 590 drugs known to interact with Latuda (lurasidone), along with 13 disease interactions, and 4 alcohol/food interactions. Of the total drug interactions, 108 are major, 481 are moderate, and 1 is minor. Hydroxyzine is an antihistamine which treats allergies, but has the sleepy qualities like a night time cold over the counter medicine would have. The trazodone doesn’t knock me out, but makes it easier to fall asleep. I’ve used both to help insomnia/ sleep paralysis. 3. Reply. Share. SessionWitty534. • 3 yr. ago. Trazodone may amplify some of the effects of alcohol, which can lead to dangerous levels of intoxication and even overdose and death. The combination can also cause extreme drowsiness, which can lead to accidents and falls. In addition, alcohol can worsen anxiety and depression. 4,10,11.Mar 26, 2024 · Cognitive impairment: In addition to making someone sleepy, Z drugs can cause loss of balance and reduced mental alertness, which may make someone prone to falls or other inadvertent injury. Dependence: People can become addicted to Z drugs, leading them to take them for longer or at higher doses than indicated. Trazodone, in particular, is frequently preferred and used in psychiatric practice. Its efficacy has mainly been demonstrated in adults with psychiatric disorders (Table 1). Trazodone is a 5-HT2A/C antagonist and is one of the most sedating antidepressants with significant morning hangover effect. Fluoxetine, on the other hand, …Applies to: Klonopin (clonazepam) and hydroxyzine. Using clonazePAM together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the …Trazodone is an antidepressant medication. It’s FDA approved to treat depression, but it’s more often used off-label for insomnia. When taken 30 minutes before bedtime, a low dose of trazodone (between 25 mg and 100 mg) may be effective for sleep problems. Trazodone is considered safe to take for short-term insomnia symptoms.I take both! I take Zoloft at night around 6pm and hydroxyzine as needed to help me sleep at night. Sometimes before I go to sleep at 10pm or in the middle of the night like 1-3am. I haven’t taken it in a few weeks as my sleep and anxiety have been much better since being on Zoloft longer. The main effect it has on me is it makes me drowsy.

Hydroxyzine has an average rating of 5.7 out of 10 from a total of 1375 ratings on Drugs.com. 46% of reviewers reported a positive effect, while 36% reported a negative effect. Mirtazapine has an average rating of 6.8 out of 10 from a total of 2023 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 21% reported a negative ...Apr 4, 2023 · Dry mouth, headache, constipation, diarrhea, and sexual dysfunction. Trazodone may cause a discontinuation syndrome if abruptly stopped, symptoms include anxiety, agitation, and sleep disturbances. When the time comes to withdraw trazodone, the dosage should be tapered off slowly under a doctor's advice. Hydroxyzine; Trazodone; Gabapentin; Ramelteon; Doxepin; When you join the program, our expert will thoughtfully select two medications based on your case. Your doctor will also schedule routine online consultations and adjust the treatment if you’re experiencing sleepless nights after starting your treatment and avoid the risk of …Dosage. Side Effects. Warnings and Interactions. Trazodone is an antidepressant in the serotonin modulators class of drugs. It is used to treat depression and works by increasing the action of serotonin in your brain. In addition to being used for managing depression, it can be used to treat insomnia and anxiety.

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hydroxyzine. hydroxyzine and trazodone both increase QTc interval. Avoid or Use Alternate Drug. idelalisib. idelalisib will increase the level or effect of trazodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.Applies to: trazodone and Cymbalta (duloxetine) Using traZODone together with DULoxetine can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or ...Trazodone and Seroquel can be taken together if prescribed by the healthcare provider. Research on their concomitant use is limited but Seroquel is often prescribed with antidepressants like trazodone. Trazodone, an antidepressant, is categorized as a serotonin antagonist and reuptake inhibitor (SARI). It is primarily used for major depressive ...How it works. Alternatives. Pregnancy. Birth control needs. Breastfeeding. Cost. How to take. Precautions. Overdose. Withdrawal and dependence. Expiration. What is hydroxyzine? Hydroxyzine is a...For oral dosage form (capsules, tablets, or solution): For anxiety and tension: Adults—50 to 100 milligrams (mg) 4 times a day. Children 6 years of age and older—50 to 100 mg per day given in divided doses. Children younger than 6 years of age—50 mg per day given in divided doses. For management of allergic reactions:

Preoperative Sedation. 0.6 mg/kg PO. 0.5-1.1 mg/kg IM. Anxiety. Symptomatic relief of anxiety associated with psychoneurosis and as adjunct in organic disease states. 50-100 mg PO divided q6hr or 50-100 mg IM divided q4-6hr. Continuation of therapy for >4 months has not been studied; reassess need for therapy periodically.Hydroxyzine: 50 to 100: 2: 20: $4: Not recommended: Antipsychotics: ... However, the evidence for trazodone is weak, and it should not be considered as first-line therapy. 38 In addition to ...How it works. Alternatives. Pregnancy. Birth control needs. Breastfeeding. Cost. How to take. Precautions. Overdose. Withdrawal and dependence. Expiration. What is hydroxyzine? Hydroxyzine is a...Trazodone, in particular, is frequently preferred and used in psychiatric practice. Its efficacy has mainly been demonstrated in adults with psychiatric disorders (Table 1). Trazodone is a 5-HT2A/C antagonist and is one of the most sedating antidepressants with significant morning hangover effect.Mar 17, 2016 · Trazodone is an antidepressant medication commonly prescribed off-label for insomnia, with typical initial dosing at 25–100 mg before bedtime. In depressed patients, 150 mg is often the initial nocturnal dose. The dosage used in depression can be titrated upward, even up to 600 mg nightly, while closely observing blood pressure. Moderator. Hydroxyzine is an antihistamine (like Benadryl, but a whole lot stronger) with the side effect of causing most people to relax/sleep... It's often used during surgery with anesthesia, and post OP. Trazadone is another med that's used mostly for sleep. So I'd suspect that these are both intended as bedtime meds. Check with your doc ...Applies to: Xanax (alprazolam) and hydroxyzine. Using ALPRAZolam together with hydrOXYzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the …Dosage. Side Effects. Warnings and Interactions. Trazodone is an antidepressant in the serotonin modulators class of drugs. It is used to treat depression and works by increasing the action of serotonin in your brain. In addition to being used for managing depression, it can be used to treat insomnia and anxiety.5 ounces of wine (12% alcohol) 1 1/2 ounces of liquor (40% alcohol) 12 ounces of beet (5% alcohol) The alcohol percent in the above drinks can certainly vary, but it gives you a good measuring stick. Therefore, if you have one drink, you want to wait at least one hour before taking trazodone. Two hours for two drinks, and so on.Dosage. Side Effects. Warnings and Interactions. Trazodone is an antidepressant in the serotonin modulators class of drugs. It is used to treat depression and works by increasing the action of serotonin in your brain. In addition to being used for managing depression, it can be used to treat insomnia and anxiety.Depending on the cause of sleep disturbance, behavioral therapy with or without adjunctive medications is the mainstay of treatment for insomnia. There are …Trazodone has been reported to cause priapism and enhanced libido while prolonging nocturnal erections (Meinhardt et al., 1999; Pyke, 2020; Vitezic and Pelcic, 2002). However, it is still unclear whether trazodone's effectiveness against erectile dysfunction is accomplished by changes in serum testosterone levels. It was shown that …

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Apr 21, 2017 · Hydroxyzine was found to block peak hERG channel tail currents in a concentration‐dependent manner, with an IC 50 of 0.39 μmol/L at near‐physiological temperature (n = 4; Fig. 1). Inhibitory effects of hydroxyzine were also observed for specific voltage‐gated sodium and calcium cardiac ion channels (Nav1.5 and Cav1.2; Fig. 1). These ... Hydroxyzine is an antihistamine that also does some stuff to serotonin, and trazodone is an antidepressant and serotonin antagonist that's also an antihistamine. After looking at the wiki pages for both, they seem pretty similar in terms of effects. For trazodone it says it is mostly a 5-HT2a antagonist at low doses.Trazodone produces transient improvement in sleep quality and sleep continuity in older patients with insomnia, but carries significant risks such as orthostatic hypotension and priapism [73,74]. For sleep-onset problem, melatonin, and synthetic melatonin agonists are the preferred therapeutic agents in older adults with insomnia [ 75 , 76 ].Atypical antidepressants are safe for most people. However, in some circumstances they can cause problems. For example: Bupropion should not be used by people who have a seizure disorder or an eating disorder such as bulimia or anorexia.; Esketamine can cause serious side effects and must be administered by a psychiatrist …Hydroxyzine may be used to relieve anxiety or itching; however, it causes sedation so can affect a person's ability to drive or operate machinery. It should not be used during …US Pharm. 2010;35(11):HS-16-HS-21. A potentially lethal condition, serotonin syndrome (SS) is caused most often when certain antidepressant agents are taken concurrently with other drugs that modulate synaptic serotonin levels. 1,2 When patients take two or more antidepressants from different pharmacologic classes, drug-drug interactions may occur; …Hydroxyzine. Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication. [8] It is used in the treatment of itchiness, insomnia, anxiety, and nausea, including that due to motion sickness. [8] It is used either by mouth or injection into a muscle. [8]

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Hydroxyzine: learn about side effects, dosage, special precautions, and more on MedlinePlus Hydroxyzine is used in adults and children to relieve itching caused by allergic skin re...We have found that hydroxyzine is effective, well tolerated, and has fewer side effects than other commonly used hypnotics. Many physicians prescribe hypnotics for hospitalized patients with insomnia. Frequently used medications include temazepam, diphenhydramine, quetiapine, and trazodone.Movies to watch while your mother sews socks in hell. Demons can be a little hard to define, and sometimes in horror the term is used as a catch-all for anything that isn’t a ghost...Jul 1, 2017 · Hydroxyzine: 50 to 100: 2: 20: $4: Not recommended: Antipsychotics: ... However, the evidence for trazodone is weak, and it should not be considered as first-line therapy. 38 In addition to ... Objective: The purpose of this systematic review is to assess the efficacy and safety of hydroxyzine for insomnia in adults. Methods: A comprehensive literature search of PubMed, Embase, and CENTRAL databases was conducted to identify relevant published studies through October 2022 using the search terms: hydroxyzine and sleep, …Hydroxyzine (Vistaril) 25 to 100: 2: 3 to 7: 37 (9 to 21) Anticholinergic, CNS depression/stimulation: No: Antidepressants: ... Trazodone is the most commonly prescribed sleep aid, but there is ...Results: The in vivo outcomes (elevated plus maze, light/dark transition, and marble burying tests) of hydroxyzine monotherapy-treated group showed a significant anxiolytic activity. The combination-treated group was found to be better than control and aripiprazole-treated groups. The combination-treated group showed a significant increase in the level of …Hydroxyzine made me very groggy. So my doc prescribed Trazodone which works fine with me. To address bedtime anxiety, suggest trying Cognitive Behavioral Therapy - Insomnia and Sleep Hypnotherapy. My experience is, CBT-i helps reduce bedtime anxiety and Sleep Hypnotherapy helps falling asleep quickly and Trazodone helps keeping me asleep. 2.Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses). Hydroxyzine is an antihistamine.Hydroxyzine made me very groggy. So my doc prescribed Trazodone which works fine with me. To address bedtime anxiety, suggest trying Cognitive Behavioral Therapy - Insomnia and Sleep Hypnotherapy. My experience is, CBT-i helps reduce bedtime anxiety and Sleep Hypnotherapy helps falling asleep quickly and Trazodone helps keeping me … ….

macOS doesn’t have a built-in utility to adjust the volume output for individual apps—but there's a workaround. When you’re trying to listen to audio using your MacBook—whether you...Medications that raise serotonin levels. One way trazodone works is by …Ziprasidone. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adagrasib. Alfentanil. Alfuzosin. Alprazolam. Amantadine.Lexapro (escitalopram) is an SSRI which can help treat symptoms of depression and anxiety disorders. Trazodone is an antidepressant of class serotonin-antagonist and reuptake inhibitors, which is approved to treat depression, sleep disorders, anxiety, fibromyalgia, etc. (2, 3) Trazodone can cause sedation, which helps manage insomnia and ...Trazodone Vs. Benadryl For Dogs. Trazodone and Benadryl are both commonly used medications for dogs, but they have different purposes. Trazodone is primarily used for anxiety and behavioral issues, while Benadryl is an antihistamine that can help with allergies and itching. If your dog is experiencing anxiety, Trazodone may be a …phenhydramine, doxylamine, and hydroxyzine, are fre-quently used for their sedative properties. Although this class of drugs is known for causing acetylcholine receptor (AChR) antagonism, it is important to note that these drugs display selectivity for the muscarinic AChR, not the nico-tinic AChR (15). In other words, while they may causeTrazodone is a widely used antidepressant that is also useful in the control of agitation and insomnia in Alzheimer's disease. This drug is now recognized as having a new mechanism of action, an effect on the unfolded protein response (UPR) pathway, restoring protein translation and slowing neurodegenerative progression in mice.Preoperative Sedation. 0.6 mg/kg PO. 0.5-1.1 mg/kg IM. Anxiety. Symptomatic relief of anxiety associated with psychoneurosis and as adjunct in organic disease states. 50-100 mg PO divided q6hr or 50-100 mg IM divided q4-6hr. Continuation of therapy for >4 months has not been studied; reassess need for therapy periodically.Hydroxyzine isn’t listed as a controlled substance by the Drug Enforcement Administration (DEA), which means the medication doesn’t entail a high risk of dependence and misuse. Plenty of drugs that are classified as controlled substances are also prescribed for sleep issues, but addiction is avoidable as long as you take them according to ... Hydroxyzine and trazodone, , Hydroxyzine is an antihistamine which treats allergies, but has the sleepy qualities like a night time cold over the counter medicine would have. The trazodone doesn’t knock me out, but makes it easier to fall asleep. I’ve used both to help insomnia/ sleep paralysis. 3. Reply. Share. SessionWitty534. • 3 yr. ago., Mar 17, 2016 · Trazodone is an antidepressant medication commonly prescribed off-label for insomnia, with typical initial dosing at 25–100 mg before bedtime. In depressed patients, 150 mg is often the initial nocturnal dose. The dosage used in depression can be titrated upward, even up to 600 mg nightly, while closely observing blood pressure. , Preoperative Sedation. 0.6 mg/kg PO. 0.5-1.1 mg/kg IM. Anxiety. Symptomatic relief of anxiety associated with psychoneurosis and as adjunct in organic disease states. 50-100 mg PO divided q6hr or 50-100 mg IM divided q4-6hr. Continuation of therapy for >4 months has not been studied; reassess need for therapy periodically., Jan 4, 2016 · Hydroxyzine was really similar to Trazodone for me. Unfortunately, because of some side effects with Trazodone, I had to stop taking it – but Hydroxyzine honestly feels very similar. Trazodone, in my experience, had a higher sedative effect for helping with sleep- but hydroxyzine’s anxiolytic (anti-anxiety) effect has been greater. , Jan 24, 2024 · Patients with a history of heart disease or those who exceed the recommended dosage may experience unwanted reactions like heart palpitations. A recent study reported that out of 47,188 people who experienced unwanted reactions to hydroxyzine, about 393 (0.83%) had heart palpitations, implying that it’s a rare adverse reaction. , Specifics of Trazodone. Trazodone is a serotonin receptor antagonist and reuptake inhibitor (SARI). The drug is believed to increase serotonergic activity in the central nervous system. It does this by inhibiting neuronal reuptake of serotonin and acting as an antagonist on the 5HT 2A subset of serotonin receptors. 1 By increasing serotonin …, The usual hydroxyzine dose for adults with sleep problems is 50 mg per day, administered 30 minutes before bedtime. For doxylamine, the typical dose for insomnia is 25 mg per day, also taken 30 minutes before bed. Hydroxyzine and doxylamine haven’t been tested for long-term use in cases of insomnia., Diphenhydramine and hydroxyzine are considered the drug of choice during pregnancy; however, it should be acknowledged that there are few studies in humans to confirm their …, Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. ... Trazodone Triclabendazole Trimipramine Triptorelin Vandetanib Vardenafil Vemurafenib Venlafaxine Vilanterol Vinflunine Voclosporin Voriconazole Vorinostat Zolpidem ..., 14-C Urea breath test: Drug information; Abacavir and lamivudine: Drug information; Abacavir, lamivudine, and zidovudine: Drug information; Abacavir: Drug information, traZODone venlafaxine. Applies to: trazodone and Effexor (venlafaxine) Using traZODone together with venlafaxine can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive ..., Please know that the combination of trazodone and hydroxyzine can cause harmful interactions, including sedation, dizziness, and drowsiness, leading to the increased likelihood of falls, cognitive impairment, and other similar issues. These drugs can also cause adverse effects such as dry mouth, blurred vision, irregular heartbeats, and ..., False-positive results for amphetamine and methamphetamine were the most commonly reported. False-positive results for methadone, opioids, phencyclidine, barbiturates, cannabinoids, and benzodiazepines were also reported in patients taking commonly used medications. The most commonly used tests to screen urine for drugs of abuse are ..., Mar 2, 2024 · In children without a comorbid psychiatric diagnosis, alpha-blockers, hydroxyzine, and trazodone were the most common medications; in older youth, trazodone was the most common medication followed by hydroxyzine, z-drugs, and SSRIs. Sleep and related prescription medications were more commonly dispensed in those with psychiatric comorbidities. , a seizure (convulsions). Side effects such as drowsiness and confusion may be more likely in older adults. Common hydroxyzine side effects may include: drowsiness; headache; dry mouth; or. skin rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects., Trazadone and Hydroxyzine together. Hello! Last night after a particularly bad time getting back to sleep I took 100mg Trazadone and 50mg Hydroxyzine. I had a terrible reaction. I couldnt walk, see, or hear, and had major stomach issues. After doing some browsing it seems a lot of people mix the two together without any adverse affects., Trazodone Interactions. There are 647 drugs known to interact with trazodone, along with 8 disease interactions, and 1 alcohol/food interaction.Of the total drug interactions, 136 are major, 496 are moderate, and 15 are minor., 14-C Urea breath test: Drug information; Abacavir and lamivudine: Drug information; Abacavir, lamivudine, and zidovudine: Drug information; Abacavir: Drug information, OBJECTIVE: Polypharmacy is common in the treatment of refractory bipolar disorder. The purpose of this article is to review the safety and efficacy of mood stabilizers in combinations. METHOD: A manual and computer (MEDLINE) search was performed for combinations of the most commonly used mood-stabilizing agents. RESULTS: The authors review safety and efficacy data on the more frequently ..., Nightmares and non-nightmare disturbed awakenings are best addressed with the anti-adrenergic agent prazosin, with doxazosin and clonidine as alternatives. First choices for difficulty initiating sleep include hydroxyzine and trazodone., In children without a comorbid psychiatric diagnosis, alpha-blockers, hydroxyzine, and trazodone were the most common medications; in older youth, trazodone was the most common medication followed by hydroxyzine, z-drugs, and SSRIs. Sleep and related prescription medications were more commonly dispensed in those with psychiatric comorbidities., , Results: The in vivo outcomes (elevated plus maze, light/dark transition, and marble burying tests) of hydroxyzine monotherapy-treated group showed a significant anxiolytic activity. The combination-treated group was found to be better than control and aripiprazole-treated groups. The combination-treated group showed a significant increase in the level of …, Because there is no harmful interaction between hydroxyzine and caffeine, it’s okay to mix hydroxyzine and coffee in many cases. “It is perfectly fine to drink coffee while taking hydroxyzine,” Dr. Cometti says. “If you are taking hydroxyzine for allergies and need to stay more awake and alert, coffee or caffeine may help a bit.”., Fear-extinction Medication - Fear-extinction medication works to inhibit the production of a protein called NMDA. Learn about NMDA and the uses for fear-extinction medication. Adve..., Trazodone is an antidepressant medication commonly prescribed off-label for insomnia, with typical initial dosing at 25–100 mg before bedtime. In depressed patients, 150 mg is often the initial nocturnal dose. The dosage used in depression can be titrated upward, even up to 600 mg nightly, while closely observing blood pressure., Applies to: hydroxyzine. Alcohol can increase the nervous system side effects of hydrOXYzine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with hydrOXYzine., Hydroxyzine made me very groggy. So my doc prescribed Trazodone which works fine with me. To address bedtime anxiety, suggest trying Cognitive Behavioral Therapy - Insomnia and Sleep Hypnotherapy. My experience is, CBT-i helps reduce bedtime anxiety and Sleep Hypnotherapy helps falling asleep quickly and Trazodone helps keeping me asleep. 2., Moderator. Hydroxyzine is an antihistamine (like Benadryl, but a whole lot stronger) with the side effect of causing most people to relax/sleep... It's often used during surgery with anesthesia, and post OP. Trazadone is another med that's used mostly for sleep. So I'd suspect that these are both intended as bedtime meds. Check with your doc ..., Mar 26, 2024 · Cognitive impairment: In addition to making someone sleepy, Z drugs can cause loss of balance and reduced mental alertness, which may make someone prone to falls or other inadvertent injury. Dependence: People can become addicted to Z drugs, leading them to take them for longer or at higher doses than indicated. , A number of venture firms are setting up to invest more during the downcycle, and Alphabet-backed GV is no exception. Startups are raising less, and less often, right now, and some..., The study uses data from the FDA. It is based on trazodone hydrochloride and hydroxyzine hydrochloride (the active ingredients of Trazodone hydrochloride and Hydroxyzine, respectively), and Trazodone hydrochloride and Hydroxyzine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered.