Gabapentin and trazodone for dogs

Intervention: Participants were randomly assigned to 6 weeks of CBT-I, trazodone, or placebo. Measurements: The primary outcome was the ISI score at 7 and 25 weeks from randomization. Results: A total of 923 patients were prescreened, and of the 411 patients with chronic insomnia, 126 were randomly assigned to CBT-I ( n = 43), …

Antidepressants ; Serotonin Antagonist-Reuptake Inhibitor ; Trazodone. 3–5 mg/kg PO Q 8–24 H or PRN. Increased anxiety; Sedation ; Selective Serotonin-Reuptake ...Trazodone is a medication commonly used to treat anxiety and stress in dogs. Learn how it works, how to give it, and what side effects to watch out for.Trazodone is a medication commonly used to treat anxiety and stress in dogs. Learn how it works, how to give it, and what side effects to watch out for.120 – 240 mg. 80 – 160 mg. 50+ lbs. 150 – 300 mg. 100 – 200 mg. Key Takeaways: Start low, go slow: Always begin at the lower end of the dosage range, especially if your dog has never taken Gabapentin before. One size does not fit all: Adjust the dosage based on your dog’s reaction and always under veterinary supervision.Gabapentin will make your pet feel calm and “chill.”. The most often reported side effects of gabapentin in dogs are sleepiness and loss of coordination. The side effects can be worse the first time your pet takes it but generally go away within 24 hours. More rarely, your pet may experience vomiting and diarrhea.

Learn how gabapentin can help dogs with seizures, pain, and anxiety. Find out how it works, what side effects it may have, and how it interacts with trazodone.Apr 17, 2023 ... As a general rule, the recommended dosage of trazodone for dogs is approximately 2.5 mg to 5 mg per pound of body weight, given every 24 hours.4. Side Effects: Keeping an Eye Out. Like any medication, Trazodone has its share of side effects, though they’re generally mild. Here’s what to watch for: Drowsiness: Your pup might be more sleepy than usual. Lethargy: A bit slower to get up and go. Gastro Issues: Rare, but possible. 5. Real Talk: The Pros & Cons.The use of gabapentin and trazodone in dogs is a topic that requires careful consideration. Both medications are commonly prescribed in veterinary medicine to address different conditions. Gabapentin: Purpose and Potential Benefits. Gabapentin is primarily used to manage neuropathic pain in canines. It works by blocking the release of certain ... Cats Benzodiazepine added to trazodone or gabapentin or pregabalin Cats Trazodone added to gabapentin or pregabalin Cats Pheromones, alpha casozepine, l-theanine, or melatonin with a single PVP or combination Examples of PVP combinations When additional sedation is needed Species Example combination Dogs Add acepromazine at 0.5-2.0mg/kg or ...

Welcome to the Introduction to Gabapentin Neurontin. Gabapentin, also known аs Neurontin, is an anticonvulsant medication used to treat seizures and nerve pain. It works by affecting chemicals and nerves in the body. Gabapentin is available in various forms, including oral solution, cаpsules, and extended-release tablets.Gabapentin Dosage for Dogs. The dosage of gabapentin will vary depending on the condition being treated and any other drugs the dog is taking. For seizure control, most dogs are dosed at 10 to 20 milligrams per kilogram of body mass every six to 12 hours. Lower doses are typically used for pain management, often ranging from 5 to …Maximum dose: 400 mg per at 1-866-832-8537 or Trazodone hydrochloride tablets are available in the following strengths: day in divided doses (2). [email protected]; or 300 mg: White, oval, flat-faced, beveled-edge tablet with one side scored with.Learn how gabapentin can help dogs with seizures, pain, and anxiety. Find out how it works, what side effects it may have, and how it interacts with trazodone.Trazodone may also be used to treat other conditions such as problems sleeping, anxiety, and panic attacks. Buy Trazodone Tablets Online - Free Worldwide Shipping Trazodone is an oral state of mind elevator considered depression, anxiety (when it's a sign of misery), in addition to for agoraphobia, panic strikes and boosted aggressiveness. Using traZODone together with gabapentin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications.

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87 °C (189 °F) Trazodone adalah obat golongan antidepresan . [7] Obat ini bisa digunakan untuk mengatasi gangguan depresi mayor, gangguan kecemasan, insomnia dan, juga bisa dikombinasikan dengan obat lain untuk mengatasi, ketergantungan alkohol . [7] [8] Trazodone bisa dikonsumsi secara oral. [7] Side Effects. See also the Warning section. Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the ... Trazodone. Trazodone is used for treating depression. It may also be used for relief of an anxiety disorder (e.g., sleeplessness, tension), chronic pain. Trazodone (brand names Desyrel, Molipaxin, Deprax, Trittico, Thombran, Trialodine, Trazorel) is a psychoactive compound with sedative, anxiolytic, and antidepressant properties.Trazodone is an antidepressant that's used off-label to calm anxiety, phobias and related behavioral disorders in dogs. Gabapentin can be used to enhance trazodone's calming effects as well as provide additional relief from anxiety-related pain or discomfort during vet visits and post-surgical confinement. Gabapentin and CBD for dogsTrazodone is generally prescribed in much lower doses for people with insomnia versus those with depression. Other medicines that are sometimes indicated for insomnia, such as benzodiazepines, come with a higher risk of inducing dependency than trazodone. Despite the lack of evidence, trazodone is generally considered to have a …

Trazodone is an antidepressant that is FDA-approved for the treatment of depression. It has been used by mental health and primary care providers for the treatment of multiple psychiatric and medical conditions .This review describes trazodone mechanism of action, formulation, dosage and adverse effects and then summarizes the beneficial effects of … Trazodone, sold under many brand names, [1] is an antidepressant medication. [20] It is used to treat major depressive disorder, anxiety disorders, and insomnia. [20] The medication is taken orally. [20] Common side effects include dry mouth, feeling faint, vomiting, and headache. [20] For depression: For oral dosage form (extended-release tablets): Adults—At first, 150 milligrams (mg) per day as a single dose. Your doctor may adjust your dose as needed. However, the dose is usually not more than 375 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 150 ... Dogs will receive Trazodone and/or Gabapentin. What to expect with the medications: Trazodone: some clients do not notice any difference in their pet, while ...Trazodone (brand name Desyrel®, Oleptro®) is a serotonin antagonist/reuptake inhibitor (SARI) antidepressant that is used to treat behavioral disorders, especially anxiety- or phobia-related in dogs (e.g., separation anxiety, noise phobia such as fireworks or thunderstorms, veterinary visits, hospitalization, and travel).Sep 20, 2023 · Trazodone for dogs is given as a pill by mouth. It comes in 50 mg, 100 mg, 150 mg, and 300 mg scored white, round tablets. The standard dosage for dogs is 5 mg/kg, given at least 1 hour before the stressful event. After trazodone is given, it generally takes 1 hour to take effect for short-term anxiety relief, but can take up to 3 hours. The reason why you love your dog. Dog owners already know in their bones that they and their pets love one another. Now, a new study has confirmed it, finding that love is chemical...Gabapentin and trazodone are medications that can be combined to treat anxiety, pain, and seizures in dogs. Learn about the potential interactions, side effects, and precautions of this combination from a veterinarian.is particularly emotionally challenged by a veterinary visit it is possible to combine trazodone with gabapentin using the following recommended dose: • Trazodone 4-12 mg/kg PO and Gabapentin 20 mg/kg PO For small dogs liquid preparations can facilitate administration of the medication and accuracy of dosing.

Gabapentin (20-25 mg/kg PO) should be administered the evening before the scheduled appointment. A combination of gabapentin (20-25 mg/kg PO) and melatonin (small dogs, 0.5-1 mg PO; medium dogs, 1-3 mg PO; large dogs, 5 mg PO) should be administered at least 1 to 2 hours before the scheduled appointment.

Maximum dose: 400 mg per at 1-866-832-8537 or Trazodone hydrochloride tablets are available in the following strengths: day in divided doses (2). [email protected]; or 300 mg: White, oval, flat-faced, beveled-edge tablet with one side scored with.The dosage for Trazodone for dogs ranges from 2.5 mg per pound to 15 mg per pound every 24 hours. It's often initially prescribed at a lower dose to minimize side effects and gradually increased over time. For safety reasons, the advised dose will often be lower when combined with other drugs. It comes in a tablet form to be taken orally with ...Intervention: Participants were randomly assigned to 6 weeks of CBT-I, trazodone, or placebo. Measurements: The primary outcome was the ISI score at 7 and 25 weeks from randomization. Results: A total of 923 patients were prescreened, and of the 411 patients with chronic insomnia, 126 were randomly assigned to CBT-I ( n = 43), …Trazodone was added gradually before sleep until the target dose of 200 mg/day. The man and his wife reported marked attenuation of the sleep bruxism. 65 When considering prescribing trazodone, attention should be paid to common side or adverse effects as reported by the FDA, such as dizziness, headache, blurred vision, …Trazodone is a serotonin antagonist/reuptake inhibitor (SARI) drug. It’s an antidepressant that vets usually prescribe to treat behavioral disorders in dogs associated with anxiety and phobias. Trazodone is a safe dog anxiety medication, and most dogs don’t experience any adverse side effects. However, some pets may experience …Trazodone is a second-generation atypical antidepressant exercising selective inhibitory action on the transport of serotonin. It also has an antagonist effect, similar to nefazodone, on the 5HT1 and 5HT2 receptors, probably due to the therapeutic effects of such substances. It is very effective in the treatment of depression, in anxiety …Trazodone produces transient improvement in sleep quality and sleep continuity in older patients with insomnia, but carries significant risks such as orthostatic hypotension and priapism [73,74]. For sleep-onset problem, melatonin, and synthetic melatonin agonists are the preferred therapeutic agents in older adults with insomnia [ 75 , 76 ].“I have an idea; tell me if it’s a bad one,” a parent in our Offspring Facebook group posted a few weeks ago. “I’m seriously thinking about getting a small dog bed for my toddler. ...Gabapentin is a human medication used by vets to treat seizures, pain, and anxiety in dogs. Learn how it works, how to dose it, and what side effects to watch …Trazodone: learn about side effects, dosage, special precautions, and more on MedlinePlus A small number of children, teenagers, and young adults (up to 24 years of age) who took a...

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Aug 7, 2020 ... Trazodone is used to help depression in people, but although it's primarily medication for humans, it has its uses in the canine world, too.ETF strategy - ALPS SECTOR DIVIDEND DOGS ETF - Current price data, news, charts and performance Indices Commodities Currencies StocksTrazodone can be lethal if more then the prescribed dose is taken, but instances are rare, according to MedlinePlus. The average dose for an outpatient adult ranges from 150 millig...For depression: For oral dosage form (extended-release tablets): Adults—At first, 150 milligrams (mg) per day as a single dose. Your doctor may adjust your dose as needed. However, the dose is usually not more than 375 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 150 ...Trazodone may cause dry mouth. For temporary relief, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth ...The present article reviewed the pharmacologic therapies of traumatic brain injury (TBI), including current and potential treatments. Pharmacologic therapies are an essential part of TBI care, and several agents have well-established effects in TBI care. In the acute phase, tranexamic acid, antiepileptics, hyperosmolar agents, and anesthetics ...Trazodone is an antidepressant that is FDA-approved for the treatment of depression. It has been used by mental health and primary care providers for the treatment of multiple psychiatric and medical conditions .This review describes trazodone mechanism of action, formulation, dosage and adverse effects and then summarizes the beneficial effects of … Gabapentin (20-25 mg/kg PO) should be administered the evening before the scheduled appointment. A combination of gabapentin (20-25 mg/kg PO) and melatonin (small dogs, 0.5-1 mg PO; medium dogs, 1-3 mg PO; large dogs, 5 mg PO) should be administered at least 1 to 2 hours before the scheduled appointment. Trazodone is used in the treatment of Depression. View Trazodone’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg.com.Trazodone. 3–8 mg/kg, prn to tid. Anticonvulsants. Carbamazepine. 4–8 mg/kg, bid-tid. 2–6 mg/kg, one to two times/day. Gabapentin. 5–30 mg/kg, bid-tid. 3–10 mg/kg, bid-tid . Levetiracetam. 20 mg/kg, tid . 10–20 mg/kg, tid . Phenobarbital d. 2–5 mg/kg, bid (to 10 mg/kg, prn for sedation) 1–3 mg/kg, bid. Potassium bromide d. 10 ...To explore the effects of trazodone on human cognition and to search for clinical evidence of its putative benefits in human neurodegenerative diseases, a systematic review was conducted for studies that evaluated the effect of a minimum dose of 25 mg of trazodone daily, for at least 1 week, on cognition in adult humans.Oct 7, 2022 · Dosage. Side Effects. Warnings and Interactions. Trazodone is an antidepressant in the serotonin modulators class of drugs. It is used to treat depression and works by increasing the action of serotonin in your brain. In addition to being used for managing depression, it can be used to treat insomnia and anxiety. ….

Starting the day after surgery, dogs were administered trazodone (~3.5 mg/kg, per os (PO), q12h) with tramadol (4–6 mg/kg, PO, q8–12h) for pain management. After 3 days, tramadol was discontinued and trazodone was increased (~7 mg/kg, PO, q12h) and maintained for at least 4 weeks. If needed, trazodone dosage was increased …Trazodone can reliably and safely induce sedation and anxiolysis in dogs and cats, making it a useful pharmacologic agent beyond the treatment of behavior problems. Indications for Trazodone in Dogs & Cats. Trazodone has been clinically used for both dogs and cats; however, its use has been more extensively researched in dogs.Trazodone is a drug used in veterinary medicine to treat dogs with behavior problems and high anxiety. This drug was initially used to treat humans, but veterinarians have more recently (in the last 10 years) started prescribing it for their canine patients. Trazodone is generally prescribed for the management of an underlying behavioral or ...Aug 7, 2020 ... Trazodone is used to help depression in people, but although it's primarily medication for humans, it has its uses in the canine world, too.If taking trazodone for the sedative effects, it works quickly, within 30 to 60 minutes. If it is being used as a treatment for depression, it can take 4 to 6 weeks to begin noticing the effects. Food delays absorption of trazodone, and taking it on a full stomach will result it it taking longer to reach full effect.Trazodone and gabapentin are both medications commonly used in veterinary medicine to manage anxiety and behavioral issues in dogs and cats. Gabapentin, traditionally used as an anticonvulsant and for neuropathic pain, has also been found to be effective in treating social anxiety and panic disorder in humans.Trazodone is a medication commonly used to treat anxiety and stress in dogs. Learn how it works, how to give it, and what side effects to watch out for.Aug 1, 2017 · Significant sleep improvement was reported during treatment with either trazodone or gabapentin: Strengths: First study to compare gabapentin and trazodone for treating insomnia in alcohol-dependent patients; required 4 weeks of abstinence to initiate participation in the study; included study follow-up. Trazodone selectively blocks serotonin reuptake, which enhances serotonin’s effects. 4 It is an antagonist of 5-HT 2A, H1-histaminic, and α1-adrenergic receptors at low to moderate doses, resulting in various levels of sedation. 3–6 It can have hypotensive effects. 4 At higher doses, trazodone acts as a serotonin agonist, and serotonin ... Gabapentin and trazodone for dogs, Gabapentin (50 – 100 mg per cat or 150 mg if big ... • Trazodone (5 – 15 mg/kg, PO, 1 hour before ... o Can be administered to dogs in the clinic; takes ~1 hour for ..., Trazodone: learn about side effects, dosage, special precautions, and more on MedlinePlus A small number of children, teenagers, and young adults (up to 24 years of age) who took a..., Sep 7, 2019 · Dosages can vary, but commonly gabapentin is dosed in dogs at 5-30 mg/kg up to three times daily,3 though in our own patients we have used 10-40 mg/kg up to three times daily as well. Gabapentin has also been used on an as-needed basis to achieve anxiolysis at 30-60 mg/kg one to two hours before an anticipated stressful event, such as a ... , Gabapentin is an anticonvulsant medication that works by decreasing abnormal excitement in the brain and changing the way the body senses pain, according to MedlinePlus. Gabapentin..., Gabapentin / Trazodone Gourmeds Chewable Tablets. Prescribed For: Dogs and Cats. May be Prescribed For: Behavioral Disorders, Anxiety and Neuropathic pain. If you have any questions concerning these medications, please consult with your doctor. Pick up or refill now. For pet owners: Pick up and fill a new prescription for your pet or refill a ..., Trazodone. Trazodone is used for treating depression. It may also be used for relief of an anxiety disorder (e.g., sleeplessness, tension), chronic pain. Trazodone (brand names Desyrel, Molipaxin, Deprax, Trittico, Thombran, Trialodine, Trazorel) is a psychoactive compound with sedative, anxiolytic, and antidepressant properties. , Overall, I highly recommend “Where to Buy Trazodone Online Now and What is it – Your Complete Guide” to anyone who is looking to purchase Trazodone online. It is a comprehensive and well-researched guide that provides all the necessary information in one place. Whether you are a first-time buyer or someone who has been using …, unusual bruising or bleeding. nosebleeds. small red or purple dots on the skin. erection lasting more than 6 hours. headache. problems with thinking, concentration, or memory. weakness. problems with coordination. Trazodone can cause painful, long lasting erections in males., Oct 20, 2022 · Serious side effects of Trazodone. Along with its needed effects, trazodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking trazodone: More common. Blurred vision ... , Gabapentin is a human medication used by vets to treat seizures, pain, and anxiety in dogs. Learn how it works, how to dose it, and what side effects to watch out for., Cats achieved peak sedation at 2 to 2.5 hours after oral administration. 2. Trazodone may be a good alternative fast-acting anxiolytic in cats that exhibited adverse events to benzodiazepines (eg, lorazepam). It may be used in similar situations as for dogs. Recommended starting dose in adult cats 7. 25 mg/cat., Jun 19, 2023 ... Dr. Sally J Foote discusses a recent study using 50mg/kg of Gabapentin as a single dose 2 hours before a veterinary exam in healthy dogs., Learn the history and ideas in common behind most methods of dog training and then talk about one of the most popular methods today: Clicker training. Advertisement Although dogs h..., Trazodone is a medication used in the management and treatment of major depressive disorder. It is in the serotonin-antagonist-and-reuptake-inhibitor class of medications. This activity reviews the indications, action, and contraindications for trazodone as a valuable agent in managing major depression. This activity will highlight the mechanism of actions, adverse effects, and other key ..., Gabapentin is used to prevent seizures, control pain, and ease anxiety in dogs. Gabapentin and trazodone are often used together to manage anxiety in dogs. Gabapentin and CBD can be beneficial for dogs individually, but using them together can increase the risk of sedation. Gabapentin and tramadol are commonly used to alleviate …, The choice between Gabapentin and dogs Trazodone (which are both FDA-approved) for dogs depends on the specific condition being treated. Gabapentin is primarily used for managing pain and seizures, while Trazodone is an anti-anxiety medication., The drug takes effect quickly, in about one to two hours, when used for short-term stress relief. However, for long-term treatment, it can take several weeks before full effects are observed. Trazodone stops working within 24 hours, but its effects can last longer in dogs with kidney or liver disease., Dec 31, 2015 · Absorption. Trazodone is rapidly absorbed in the gastrointestinal tract after oral administration, with a bioavailability ranging from 63-91% 9 and an AUC0−t of 18193.0 ng·h/mL. 17 Food may impact absorption in a variable fashion, and may sometimes lead to decreases in the Cmax of trazodone. 9,16 In the fed state in 8 healthy volunteers, the Cmax was measured to be 1.47 +/- 0.16 micrograms ... , Significant sleep improvement was reported during treatment with either trazodone or gabapentin: Strengths: First study to compare gabapentin and trazodone for treating insomnia in alcohol-dependent patients; required 4 weeks of abstinence to initiate participation in the study; included study follow-up. Limitations: Small sample; non ..., Trazodone Dosage and Administration. Starting dose: 150 mg in divided doses daily. May be increased by 50 mg per day every three to four days. Maximum dose: 400 mg per day in divided doses ( 2.1 ). Trazodone hydrochloride tablets should be taken shortly after a meal or light snack ( 2.2 )., gabapentin. gabapentin, trazodone. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation., Trazodone (brand name Desyrel®, Oleptro®) is a serotonin antagonist/reuptake inhibitor (SARI) antidepressant that is used to treat behavioral disorders, especially anxiety- or phobia-related in dogs (e.g., separation anxiety, noise phobia such as fireworks or thunderstorms, veterinary visits, hospitalization, and travel). , Trazodone can reliably and safely induce sedation and anxiolysis in dogs and cats, making it a useful pharmacologic agent beyond the treatment of behavior problems. Indications for Trazodone in Dogs & Cats. Trazodone has been clinically used for both dogs and cats; however, its use has been more extensively researched in dogs., In 1981, trazodone (the generic name of the pharmaceutical) was approved by the U.S. Food and Drug Administration (FDA) under the brand name Desyrel for use in treating major depressive disorder. Today, the medication is prescribed under the brand name Oleptro to treat sleep disorders such as insomnia as well as anxiety disorder and …, Dec 31, 2015 · Absorption. Trazodone is rapidly absorbed in the gastrointestinal tract after oral administration, with a bioavailability ranging from 63-91% 9 and an AUC0−t of 18193.0 ng·h/mL. 17 Food may impact absorption in a variable fashion, and may sometimes lead to decreases in the Cmax of trazodone. 9,16 In the fed state in 8 healthy volunteers, the Cmax was measured to be 1.47 +/- 0.16 micrograms ... , Dec 31, 2015 · Absorption. Trazodone is rapidly absorbed in the gastrointestinal tract after oral administration, with a bioavailability ranging from 63-91% 9 and an AUC0−t of 18193.0 ng·h/mL. 17 Food may impact absorption in a variable fashion, and may sometimes lead to decreases in the Cmax of trazodone. 9,16 In the fed state in 8 healthy volunteers, the Cmax was measured to be 1.47 +/- 0.16 micrograms ... , Abstract. A fatal case of suicide with trazodone alone in a 40-year-old patient is reported. Life-threatening arrhythmias, such as torsades de pointes and complete AV block, are recorded. Blood collected at admission contained a trazodone toxic concentration of 25.4 micrograms/mL. The patient developed multiple organ failure and died less than ..., A psychiatric service dog specifically for bipolar disorder? Yes, it's an option. Here's what to know. It’s possible to have a service dog that can recognize and help with bipolar ..., Gabapentin and trazodone are commonly used for this purpose. Dosages for these and other previsit pharmaceuticals are listed in here. Feeding and treatment recommendations for dogs and cats prior to anesthesia. Recommendations for Chronic Medications the Day of Anesthesia* Expand All / Collapse All., Trazodone takes effect quickly, typically within 1–2 hours of administration. Sileo ® (Dexmedetomidine oralmucosal gel) Sileo is an alpha-2 adrenoceptor agonist. This gel is administered 30–60 minutes prior to the phobic event (or immediately if unexpected). Relief is often seen within minutes of administration. Gabapentin, A 10 pound dog may receive as little as 50 mg of gabapentin prior to a veterinary visit, while a 100 pound dog with severe pain may receive as much as 1000 mg of gabapentin every eight hours. Gabapentin is typically given every eight to twelve hours, with peak benefits occurring roughly two hours after dosing., Gabapentin will make your pet feel calm and “chill.”. The most often reported side effects of gabapentin in dogs are sleepiness and loss of coordination. The side effects can be worse the first time your pet takes it but generally go away within 24 hours. More rarely, your pet may experience vomiting and diarrhea., To explore the effects of trazodone on human cognition and to search for clinical evidence of its putative benefits in human neurodegenerative diseases, a systematic review was conducted for studies that evaluated the effect of a minimum dose of 25 mg of trazodone daily, for at least 1 week, on cognition in adult humans.