Lubiprostone interactions

Apr 25, 2013 · Interaction potential with diphenylheptane opioids (e.g. methadone): Non-clinical studies have shown opioids of the diphenylheptane chemical class (e.g., methadone) to dose-dependently reduce the activation of ClC-2 by lubiprostone in the gastrointestinal tract.

Lubiprostone interactions. Interactions for Amitiza vs. Linzess Amitiza. Amitiza is generally considered safe and is a known Linzess alternative. However, there are some known significant interactions: ... Amitiza (lubiprostone) and Linzess (linaclotide) are medications used to treat chronic constipation conditions. They share the same therapeutic goals and can …

Side effects. Brand names. FAQ. Uses for lubiprostone. Lubiprostone is used to treat long-lasting constipation in adults.

Lubiprostone is a chloride channel activator indicated for the treatment of: chronic idiopathic constipation (CIC) in adults. ( 1.1) opioid-induced constipation (OIC) in adult patients with chronic, non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g., weekly) opioid dosage …Lubiprostone may rarely cause trouble breathing and chest tightness within 30 to 60 minutes after the first dose. This reaction is usually not serious and generally goes away within 3 hours. It ...Lubiprostone is used to relieve stomach pain, bloating, and straining and produce softer and more frequent bowel movements in people who have chronic idiopathic constipation (difficult or infrequent passage of stools that lasts for 3 months or longer and is not caused by a disease or a medication). Lubiprostone is also used to treat irritable ...People react to their environment in a variety of ways. The environment sometimes shape these interactions. Sustainability efforts exist to help humans co-exist peacefully with the...Dec 28, 2018 ... Lubiprostone, Linaclotide. What form(s) does ... Drug interactions of Amitiza vs. Linzess ... This is not a complete list of potential drug ...Lubiprostone could not be detected in plasma; however, M3 has a t ½ ranging from 0.9 to 1.4 hours. After a single oral dose of 72 mcg of 3 H-labeled lubiprostone, 60% of total administered radioactivity was recovered in the urine within 24 hours and 30% of total administered radioactivity was recovered in the feces by 168 hours. Lubiprostone ...Amitiza (lubiprostone) is a prescription drug that’s used to treat certain kinds of constipation in adults. Amitiza can cause side effects that range from mild to serious. ... drug interactions ...The cost for lubiprostone oral capsule 8 mcg is around $67 for a supply of 60 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.

Lubiprostone is used to relieve stomach pain, bloating, and straining and produce softer and more frequent bowel movements in people who have chronic idiopathic constipation (difficult or infrequent passage of stools that lasts for 3 months or longer and is not caused by a disease or a medication). Lubiprostone is also used to treat irritable ...Pharmacokinetic interactions. A large amount of the data regarding the possible pharmacokinetic interactions of linaclotide, lubiprostone and prucalopride comes from in vitro studies. Although this is a useful guide, in vitro results do not always reflect what happens in clinical use. This data should therefore be interpreted with caution until ...Oct 9, 2023 · Interactions. FAQ. What is lubiprostone? Lubiprostone is used to treat chronic constipation, or constipation caused by opioid pain medicine. Lubiprostone may also be used to treat irritable bowel syndrome in women with constipation as the main symptom. Lubiprostone may also be used for purposes not listed in this medication guide. StudyIQ Live is an online learning platform that offers a wide range of courses and study materials for students of all ages. One of the standout features of StudyIQ Live is its li...May 11, 2012 · Side Effects of Lubiprostone. The most common side effects of taking l ubiprostone are nausea, diarrhea, and abdominal pain. Within an hour of taking l ubiprostone, a sensation of chest tightness and shortness of breath may occur. These symptoms usually go away within three hours, but may recur with repeated use. Lubiprostone is a medication used in the management of idiopathic chronic constipation. A prostaglandin E1 derivative, lubiprostone is a bicyclic fatty acid that activates ClC-2 chloride channels located on the apical side of the gastrointestinal epithelial cells. A total of 1 drugs are known to interact with lubiprostone: 1 moderate drug interactions (2 brand and generic names) A total of 4 drugs are known to interact with docusate: 3 moderate drug interactions (27 brand and generic names) 1 minor drug interactions (2 brand and generic names) A total of 219 drugs are known to interact with MiraLAX:Study with Quizlet and memorize flashcards containing terms like Class of Amitiza, Therapeutic uses of lubiprostone, 4 Adverse drug reactions of lubiprostone and more.

Lubiprostone Interactions. There are 1 drugs known to interact with lubiprostone, along with 4 disease interactions. Of the total drug interactions, 1 is moderate. Does lubiprostone interact with my other drugs? Enter other medications to view a detailed report. View lubiprostone disease interactions (4) See moreNo in vivo interaction studies have been conducted. The effectiveness of lubiprostone in the treatment of OIC in patients taking ... there is low likelihood of pharmacokinetic drug–drug interactions with lubiprostone. Additionally, in vitro studies in human liver microsomes demonstrate that lubiprostone does not inhibit cytochrome ...Find patient medical information for lubiprostone oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.Lubiprostone could not be detected in plasma; however, M3 has a t ½ ranging from 0.9 to 1.4 hours. After a single oral dose of 72 mcg of 3 H-labeled lubiprostone, 60% of total administered radioactivity was recovered in the urine within 24 hours and 30% of total administered radioactivity was recovered in the feces by 168 hours. Lubiprostone ...Feb 1, 2024 · Dry heaves. dry mouth. feeling of warmth. lack or loss of strength. paleness of the skin. redness of the face, neck, arms, and occasionally, upper chest. severe, unusual tiredness or weakness. weight loss. Some side effects may occur that usually do not need medical attention.

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Lubiprostone is used to relieve stomach pain, bloating, and straining and produce softer and more frequent bowel movements in people who have chronic idiopathic constipation …Medscape - IBS-C, OIC, or CIC dosing for Amitiza (lubiprostone), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.Side effects. Warnings. Before taking. Dosage. Interactions. FAQ. What is lubiprostone? Lubiprostone is used to treat chronic constipation, or constipation caused by opioid pain medicine. Lubiprostone may also be used to treat irritable bowel syndrome in women with constipation as the main symptom.Lubiprostone is a medication used in the management of …We study 836 people who take Lubiprostone or Hydralazine hydrochloride w/ hydrochlorothiazide 25/25. There is no drug interaction reported. The phase IV clinical study analyzes what interactions people who take Lubiprostone and Hydralazine hydrochloride w/ hydrochlorothiazide 25/25 have.

lower back or side pain. muscle cramps. muscle stiffness. stomach upset. swollen joints. tingling of the hands or feet. unusual drowsiness, dullness, tiredness, or feeling of sluggishness. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.Are you looking for a fun and interactive way to help your child learn how to write their name? Look no further. Free name tracing printables are a fantastic tool that can make lea...Lubiprostone (Ingredient) Chemical formula: C20H32F2O5 Drugbank ID: DB01046 ATC code: A06AX03. The information below refers to products available in the United States that contain lubiprostone. Products containing lubiprostone lubiprostone systemic. Brand name: Amitiza Drug class: chloride channel activators. Lubiprostone systemic is used in ...Description: Mechanism of Action: Lubiprostone is a selective, locally-acting chloride-channel activator acting on the apical (luminal) part of gastrointestinal epithelium that increases the secretion of chloride-containing intestinal fluid without changing the serum concentration of Na and K.This increases intestinal motility, thus aiding the passage of …The Earth’s four spheres interact in all six possible combinations: lithosphere and hydrosphere, lithosphere and biosphere, lithosphere and atmosphere, hydrosphere and biosphere, h...Side effects. Images. Storage. What is lubiprostone used for? Lubiprostone is used to treat constipation. It is used to treat irritable bowel syndrome. Before taking lubiprostone, …Oct 9, 2023 · Interactions. FAQ. What is lubiprostone? Lubiprostone is used to treat chronic constipation, or constipation caused by opioid pain medicine. Lubiprostone may also be used to treat irritable bowel syndrome in women with constipation as the main symptom. Lubiprostone may also be used for purposes not listed in this medication guide. Find information on Lubiprostone (Amitiza) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.May 25, 2022 · Lubiprostone capsules are a chloride channel activator indicated for the treatment of: chronic idiopathic constipation (CIC) in adults. opioid-induced constipation (OIC) in adult patients with chronic, non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g., weekly) opioid dosage escalation. Mechanism of Action: Lubiprostone is a selective, locally-acting chloride-channel activator acting on the apical (luminal) part of gastrointestinal epithelium that increases the secretion of chloride-containing intestinal fluid without changing the serum concentration of Na and K. This increases intestinal motility, thus aiding the passage of ...Find information on Lubiprostone (Amitiza) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.

Lubiprostone may rarely cause trouble breathing and chest tightness within 30 to 60 minutes after the first dose. This reaction is usually not serious and generally goes away within 3 hours. It ...

Medscape - IBS-C, OIC, or CIC dosing for Amitiza (lubiprostone), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.Amitiza (lubiprostone) is a prescription drug that’s used to treat certain kinds of constipation in adults. Amitiza can cause side effects that range from mild to serious. ... drug interactions ... This medicine works by increasing the fluid secretion of the bowels, which helps ease the passage of stool and helps relieve the symptoms associated with constipation. Lubiprostone is also used to treat irritable bowel syndrome (IBS) in women who have constipation as the main symptom. This medicine is available only with your doctor's prescription. Feb 20, 2024 · Drug Interactions Drugs Affecting or Metabolized by Hepatic Microsomal Enzymes. Does not inhibit CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4 in vitro. Does not induce CYP1A2, CYP2B6, CYP2C9, or CYP3A4 in vitro. Pharmacokinetic interactions unlikely with drugs metabolized by these CYP isoenzymes. Not metabolized by isoenzymes. Precautions. Drug information provided by: Merative, Micromedex ®. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects. Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting ...Oct 9, 2023 · Interactions. FAQ. What is lubiprostone? Lubiprostone is used to treat chronic constipation, or constipation caused by opioid pain medicine. Lubiprostone may also be used to treat irritable bowel syndrome in women with constipation as the main symptom. Lubiprostone may also be used for purposes not listed in this medication guide. Amitiza (lubiprostone) is a chloride channel activator used to treat idiopathic (due to an unknown cause) chronic constipation. Common side effects of Amitiza include nausea, diarrhea, headache, frequent bowel movements, fecal incontinence, gas (flatulence), decreased appetite, and rash. Use of Amitiza in pregnant women has not been …Grapefruit Overview. Grapefruit is a tropical citrus fruit known for its tart and tangy flavor. They are a good source of vitamin C and other nutrients, including vitamin A, potassium, and fiber. There are several varieties of grapefruits, including white, pink, and red. This color difference is mostly attributed to their respective lycopene ...

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Lubiprostone (brand name: ... Analysis of covariance (*p<0.05) or Welch test (baseline, or due to significant interaction between grouping variable and covariate; day 14 and day 28 of lactulose excretion rate and day 28 of mannitol excretion rate) were used for statistical analysis. Abbreviations: LMR, lactulose-mannitol ratio.Jun 27, 2018 ... Lubiprostone is also known by the brand name: Amitiza. Lubiprostone comes in 8 and 24 mcg capsules. Lubiprostone is most commonly used for ...Lubiprostone (brand name: ... Analysis of covariance (*p<0.05) or Welch test (baseline, or due to significant interaction between grouping variable and covariate; day 14 and day 28 of lactulose excretion rate and day 28 of mannitol excretion rate) were used for statistical analysis. Abbreviations: LMR, lactulose-mannitol ratio. A member of your care team will answer Monday through Friday from 9 a.m. to 5 p.m. Outside those hours, you can leave a message or talk with another MSK provider. There is always a doctor or nurse on call. If you’re not sure how to reach your healthcare provider, call 212-639-2000. Aug 1, 2019 ... Amitiza (lubiprostone)*. Lactulose generic ... contraindication, drug-drug interaction ... drug-drug-interactions or intolerable side effects with ...Find patient medical information for lubiprostone oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.In today’s digital age, where typing has become an essential skill for both personal and professional use, there is a growing demand for interactive ways to improve typing speed an...Side Effects of Lubiprostone. The most common side effects of taking l ubiprostone are nausea, diarrhea, and abdominal pain. Within an hour of taking l ubiprostone, a sensation of chest tightness and shortness of breath may occur. These symptoms usually go away within three hours, but may recur with repeated use.History of stool (fecal) impaction. Liver disease. Stomach cancer. An unusual or allergic reaction to lubiprostone, other medications, foods, dyes, or preservatives. Pregnant or trying to get pregnant. Breast-feeding. How should I use this medication? Take this medication by mouth with water.lubiprostone: Amitiza Pharmacologic class: Chloride channel activator Therapeutic class: GI motility enhancer Pregnancy risk category C Action Enhances chloride-rich intestinal fluid secretion without altering sodium and potassium serum concentrations; increases intestinal fluid secretion and intestinal motility, which promotes stool passage ...In today’s digital age, where typing has become an essential skill for both personal and professional use, there is a growing demand for interactive ways to improve typing speed an...Summary: Drug interactions are reported only by a few people who take Tadalafil and Lubiprostone together. The phase IV clinical study analyzes what interactions people who take Tadalafil and Lubiprostone have. It is created by eHealthMe based on reports of 2 people who take the same drugs from the FDA, and is updated regularly. ….

With risks like these, it’s helpful to be aware of methylpredisolone’s top interactions. 1. Blood thinners. Blood thinners are used to prevent and treat blood clots. Examples include warfarin (Coumadin, Jantoven), apixaban (Eliquis), and rivaroxaban (Xarelto). Methylprednisolone can change how blood thinners work in the body.Television commercials have come a long way since their inception. From simple black and white advertisements to interactive experiences, the evolution of television commercials ha...Pare de tomar lubiprostone y llame a su médico si se siente mareado después de cada dosis o si tiene diarrea severa. Los efectos secundarios comunes pueden incluir: náuseas, dolor de estómago; diarrea, gas, distensión abdominal; o. dolor de cabeza. Esta lista no incluye todos los efectos secundarios y es posible que aparezcan otros síntomas.Lubiprostone is a chloride channel activator indicated for the treatment of: chronic idiopathic constipation (CIC) in adults. ( 1.1) opioid-induced constipation (OIC) in adult patients with chronic, non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g., weekly) opioid dosage …May 11, 2012 · Side Effects of Lubiprostone. The most common side effects of taking l ubiprostone are nausea, diarrhea, and abdominal pain. Within an hour of taking l ubiprostone, a sensation of chest tightness and shortness of breath may occur. These symptoms usually go away within three hours, but may recur with repeated use. Thus, methadone does not act by competition with lubiprostone, suggesting possible interaction between methadone and hClC-2 (or a closely related process required for activation of hClC-2 dependent Cl − currents). Further studies will be required to determine if hClC-2 interacts directly with methadone. These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. Major: Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Moderate Lubiprostone acts by specifically activating ClC-2 chloride channels, which is a normal constituent of the apical membrane of the human intestine, in a protein kinase A action independent fashion. Activation of ClC-2 chloride channels causes an efflux of chloride ions into the lumen, which in turn leads to an efflux of sodium ions through a paracellular … Lubiprostone interactions, In today’s digital age, technology has revolutionized the way we approach education. Traditional methods of teaching are being replaced by interactive platforms that engage student..., Here's a look at the 20 busiest airports and the change in passengers from airport to airport to see which destinations have become popular for each origin. We may be compensated w..., Objectives: To examine the efficacy and safety of lubiprostone for the treatment of opioid-induced constipation (OIC) in patients by opioid class received. Design: Data were pooled from three phase III, randomized, double-blind, placebo-controlled studies. Subjects/setting: Adults with chronic noncancer pain receiving opioid therapy for …, Lubiprostone could not be detected in plasma; however, M3 has a t ½ ranging from 0.9 to 1.4 hours. After a single oral dose of 72 mcg of 3 H-labeled lubiprostone, 60% of total administered radioactivity was recovered in the urine within 24 hours and 30% of total administered radioactivity was recovered in the feces by 168 hours. Lubiprostone ..., Summary: Drug interactions are reported only by a few people who take Tadalafil and Lubiprostone together. The phase IV clinical study analyzes what interactions people who take Tadalafil and Lubiprostone have. It is created by eHealthMe based on reports of 2 people who take the same drugs from the FDA, and is updated regularly., History of stool (fecal) impaction. Liver disease. Stomach cancer. An unusual or allergic reaction to lubiprostone, other medications, foods, dyes, or preservatives. Pregnant or trying to get pregnant. Breast-feeding. How should I use this medication? Take this medication by mouth with water., 7 DRUG INTERACTIONS 7.1 Methadone ... Based upon the results of in vitro human microsome studies, there is low likelihood of pharmacokinetic drug-drug interactions with lubiprostone. Additionally, in vitro studies in human liver microsomes demonstrate that lubiprostone does not inhibit cytochrome P450 isoforms 3A4, 2D6, …, There were no interactions found between lubiprostone and Delta-9-tetrahydrocannabinol (thc). This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your …, Apr 5, 2021 · Interactions between Lubiprostone (Amitiza) and other drugs Lubiprostone (Amitiza) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently ... , 7 DRUG INTERACTIONS . 7.1. Methadone . 8 USE IN SPECIFIC POPULATIONS . 8.1 Pregnancy . 8.2 Lactation . 8.4 Pediatric Use . 8.5 Geriatric Use . 8.6 Hepatic Impairment . ... Amitiza is available as an oval, gelatin capsule containing 8 mcg or 24 mcg of lubiprostone. • 8 mcg capsules are pink and are printed with “SPI” on one side, Taking linaclotide with food may increase gastrointestinal side effects such as diarrhea, abdominal pain, and gas. The absorption of any other oral medication you may take can be affected if you develop frequent or severe diarrhea. To reduce the risk of gastrointestinal intolerance, linaclotide should be taken on an empty stomach at least 30 ..., Are you looking to enhance your coding skills in the C programming language? Look no further. In this article, we will explore a collection of interactive C program examples that w..., No in vivo interaction studies have been conducted. The effectiveness of lubiprostone in the treatment of OIC in patients taking ... there is low likelihood of pharmacokinetic drug–drug interactions with lubiprostone. Additionally, in vitro studies in human liver microsomes demonstrate that lubiprostone does not inhibit cytochrome ..., Feb 1, 2024 · Other Interactions . Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. , 7 DRUG INTERACTIONS 7.1 Methadone ... Based upon the results of in vitro human microsome studies, there is low likelihood of pharmacokinetic drug-drug interactions with lubiprostone. Additionally, in vitro studies in human liver microsomes demonstrate that lubiprostone does not inhibit cytochrome P450 isoforms 3A4, 2D6, …, Pare de tomar lubiprostone y llame a su médico si se siente mareado después de cada dosis o si tiene diarrea severa. Los efectos secundarios comunes pueden incluir: náuseas, dolor de estómago; diarrea, gas, distensión abdominal; o. dolor de cabeza. Esta lista no incluye todos los efectos secundarios y es posible que aparezcan otros síntomas., Lubiprostone is a chloride channel activator indicated for the treatment of: chronic idiopathic constipation (CIC) in adults. (opioid-induced constipation (OIC) in adult patients with chronic, non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g., weekly) opioid dosage escalation., Lubiprostone is a medication used in the management of …, Find everything you need to know about Lubiprostone, including what it is used for, warnings, reviews, side effects, and interactions. Learn more about Lubiprostone at EverydayHealth.com., Lubiprostone Images. lubiprostone 8 mcg; lubiprostone 8 mcg; lubiprostone 24 mcg; lubiprostone 8 mcg; lubiprostone 24 mcg; Drug Interactions. Levomethadone: May diminish the therapeutic effect of Lubiprostone. Monitor therapy. Methadone: May diminish the therapeutic effect of Lubiprostone. Monitor therapy. Adverse Reactions >10%:, Taking linaclotide with food may increase gastrointestinal side effects such as diarrhea, abdominal pain, and gas. The absorption of any other oral medication you may take can be affected if you develop frequent or severe diarrhea. To reduce the risk of gastrointestinal intolerance, linaclotide should be taken on an empty stomach at least 30 ..., Lubiprostone is a novel selective chloride channel-2 activator that increases fluid secretion in the intestinal apical cell membrane, increasing gut motility and frequency of stool passage, and alleviating abdominal discomfort/pain. Lubiprostone has very low systemic bioavailability and cannot be quantitated in blood, but its active metabolite ... , Are you dreaming of designing your own house but not sure where to start? Look no further. Thanks to the wonders of technology, you can now design your dream home with the help of ..., Short-circuit current (Isc) was recorded in Ussing chambers as a marker for chloride secretion during pharmacological interactions between morphine and lubiprostone. Measurements of fecal wet weight were used to obtain information on morphine-lubiprostone interactions in conscious mice. Morphine decreased basal Isc, with an …, This is not a list of all drugs or health problems that interact with this drug. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. , Geriatric. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lubiprostone in the elderly. Breastfeeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. , Lubiprostone This information from Lexicomp explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and ... This is not a list of all drugs or health problems that interact with this drug. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural ..., Docusate is a medication utilized for managing and treating constipation. Belonging to the stool softener class of drugs, it reduces the surface tension of the oil and water interface within the stool, facilitating the passage of water and lipids into the stool mass. The goal is for the stool to become softer and move through the intestinal tract …, Amitiza (lubiprostone) is a brand-name prescription medication that's used to treat certain types of constipation. It comes as an oral capsule you take once or twice daily. Learn about side ..., Lubiprostone (Amitiza) is a prostaglandin derivative that reduces constipation and improves stool consistency by activating specific chloride channels (ClC-2) in the small intestine to increase ..., History of stool (fecal) impaction. Liver disease. Stomach cancer. An unusual or allergic reaction to lubiprostone, other medications, foods, dyes, or preservatives. Pregnant or trying to get pregnant. Breast-feeding. How should I use this medication? Take this medication by mouth with water., There are no known drug-drug interactions identified to date. A study evaluating lubiprostone 24 μg BID to placebo for a period of 4 weeks in 237 subjects (119/118) with chronic constipation showed that the most common adverse events were nausea (21%), abdominal pain (6.7%) and dyspnea (3.4%)., Lubiprostone may rarely cause trouble breathing and chest tightness within 30 to 60 minutes after the first dose. This reaction is usually not serious and generally goes away within 3 hours. It ...